ENSMUSG00000029249


Mus musculus

Features
Gene ID: ENSMUSG00000029249
  
Biological name :Rest
  
Synonyms : Q8VIG1 / RE1-silencing transcription factor / Rest
  
Possible biological names infered from orthology : Q13127
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.3
Gene start: 77265491
Gene end: 77286432
  
Corresponding Affymetrix probe sets: 10522712 (MoGene1.0st)   1425564_at (Mouse Genome 430 2.0 Array)   1425565_at (Mouse Genome 430 2.0 Array)   1425566_at (Mouse Genome 430 2.0 Array)   1428227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079231
Ensembl peptide - ENSMUSP00000109076
NCBI entrez gene - 19712     See in Manteia.
MGI - MGI:104897
RefSeq - XM_006534842
RefSeq - NM_011263
RefSeq Peptide - NP_035393
swissprot - Q8VIG1
Ensembl - ENSMUSG00000029249
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 restENSDARG00000103046Danio rerio
 ENSGALG00000032982Gallus gallus
 RESTENSG00000084093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfp407 / zinc finger protein 407 / Q9C0G0* / ZNF407*ENSMUSG0000004841010


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR027757  RE1-silencing transcription factor
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0032348 negative regulation of aldosterone biosynthetic process ISS
 biological_processGO:0035690 cellular response to drug ISS
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043922 negative regulation by host of viral transcription ISS
 biological_processGO:0045665 negative regulation of neuron differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis ISS
 biological_processGO:0046676 negative regulation of insulin secretion ISS
 biological_processGO:0050768 negative regulation of neurogenesis IGI
 biological_processGO:0060379 cardiac muscle cell myoblast differentiation IDA
 biological_processGO:0070933 histone H4 deacetylation ISS
 biological_processGO:0071257 cellular response to electrical stimulus ISS
 biological_processGO:0071385 cellular response to glucocorticoid stimulus ISS
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:2000065 negative regulation of cortisol biosynthetic process ISS
 biological_processGO:2000706 negative regulation of dense core granule biogenesis ISS
 biological_processGO:2000740 negative regulation of mesenchymal stem cell differentiation ISO
 biological_processGO:2000798 negative regulation of amniotic stem cell differentiation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0015271 outward rectifier potassium channel activity ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: EdaTa-36H/Y
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0002983 increased retinal ganglion cell number "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

 MP:0004203 abnormal cranial flexure "any structural abnormality or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [J:10730, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa-36H/Y
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa-36H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Resttm1.1Yasu/Resttm1.2Yasu,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0008508 thick retinal ganglion layer "increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lta/Tnftm1Eug/Lta/Tnftm1Eug
Genetic Background: involves: 129 * C57BL/6J

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Resttm1.1Jhsi/Resttm1.1Jhsi,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan,Resttm1.1Whk/Resttm1.1Whk,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Resttm1.1Jhsi/Resttm1.1Jhsi,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Resttm1.1Jhsi/Resttm1.1Jhsi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

Allelic Composition: Resttm1Ymat/Resttm1Ymat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011610 abnormal primordial germ cell apoptosis "change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb]
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Allelic Composition: Resttm1Ymat/Resttm1Ymat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Resttm1.1Yasu/Resttm1.2Yasu,Alpltm1(cre)Nagy/Alpl+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Myctm2Dmlo/Myctm2Dmlo
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019777 Hdac2 / histone deacetylase 2 / Q92769*  / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex
 ENSMUSG00000037896 Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex






 

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