ENSMUSG00000036940


Mus musculus

Features
Gene ID: ENSMUSG00000036940
  
Biological name :Kdm1a
  
Synonyms : Kdm1a / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / Q6ZQ88
  
Possible biological names infered from orthology : lysine demethylase 1A / O60341
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 136550540
Gene end: 136602723
  
Corresponding Affymetrix probe sets: 10517465 (MoGene1.0st)   1426761_at (Mouse Genome 430 2.0 Array)   1426762_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131385
Ensembl peptide - ENSMUSP00000035457
Ensembl peptide - ENSMUSP00000101473
Ensembl peptide - ENSMUSP00000111977
Ensembl peptide - ENSMUSP00000114268
NCBI entrez gene - 99982     See in Manteia.
MGI - MGI:1196256
RefSeq - NM_133872
RefSeq - XM_006539331
RefSeq - XM_006539330
RefSeq - XM_006539329
RefSeq - NM_001347221
RefSeq - NM_001356567
RefSeq Peptide - NP_001334150
RefSeq Peptide - NP_001343496
RefSeq Peptide - NP_598633
swissprot - F6ZC60
swissprot - Q6ZQ88
swissprot - A3KG93
swissprot - F6Z4I3
swissprot - G8JL40
Ensembl - ENSMUSG00000036940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm1aENSDARG00000060679Danio rerio
 KDM1AENSGALG00000033469Gallus gallus
 KDM1AENSG00000004487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm1b / Q8CIG3 / Lysine-specific histone demethylase 1B / Q8NB78* / lysine demethylase 1B*ENSMUSG0000003808025
Smox / Q99K82 / spermine oxidase / Q9NWM0*ENSMUSG0000002733317
Paox / Q8C0L6 / Mus musculus polyamine oxidase (exo-N4-amino) (Paox), transcript variant 2, mRNA. / Q6QHF9* / polyamine oxidase*ENSMUSG0000002546415


Protein motifs (from Interpro)
Interpro ID Name
 IPR002937  Amine oxidase
 IPR007526  SWIRM domain
 IPR009057  Homeobox-like domain superfamily
 IPR017366  Histone lysine-specific demethylase
 IPR036188  FAD/NAD(P)-binding domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006482 protein demethylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IEA
 biological_processGO:0010725 regulation of primitive erythrocyte differentiation IMP
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030851 granulocyte differentiation IMP
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0033169 histone H3-K9 demethylation IEA
 biological_processGO:0033184 positive regulation of histone ubiquitination IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034720 histone H3-K4 demethylation IEA
 biological_processGO:0035563 positive regulation of chromatin binding IEA
 biological_processGO:0042551 neuron maturation IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IMP
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046098 guanine metabolic process IEA
 biological_processGO:0046886 positive regulation of hormone biosynthetic process IMP
 biological_processGO:0050767 regulation of neurogenesis IGI
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051572 negative regulation of histone H3-K4 methylation IMP
 biological_processGO:0051573 negative regulation of histone H3-K9 methylation IMP
 biological_processGO:0055001 muscle cell development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:1903758 negative regulation of transcription from RNA polymerase II promoter by histone modification IC
 biological_processGO:1903827 regulation of cellular protein localization IEA
 biological_processGO:1990138 neuron projection extension IMP
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 biological_processGO:2000648 positive regulation of stem cell proliferation IMP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:1990391 DNA repair complex IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0032451 demethylase activity IEA
 molecular_functionGO:0032452 histone demethylase activity IEA
 molecular_functionGO:0032453 histone demethylase activity (H3-K4 specific) IEA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IEA
 molecular_functionGO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0043426 MRF binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0061752 telomeric repeat-containing RNA binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
HDMs demethylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Dnmt1tm2Jae/Dnmt1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Egln1tm1.1Fsl/Egln1+,Hif1atm3.1Rsjo/Hif1a+
Genetic Background: B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Egln1tm1.1Fsl/Egln1+,Hif1atm3.1Rsjo/Hif1a+
Genetic Background: B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001657 abnormal induced morbidity/mortality "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
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Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Kdm1aGt(RRK075)Byg/Kdm1aGt(RRK075)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kdm1aGt(RRK075)Byg/Kdm1atm1.2Rsd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Fsl/Egln1+,Hif1atm3.1Rsjo/Hif1a+
Genetic Background: B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003965 abnormal pituitary hormone level "aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003969 abnormal lutenizing hormone level 
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129 * C57BL/6 * CBA/Ca

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Kctd15tm1b(EUCOMM)Wtsi/Kctd15tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kctd15tm1b(EUCOMM)Wtsi/Ucd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kdm1aGt(RRK075)Byg/Kdm1atm1.2Rsd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Kdm1atm1.2Tche/Kdm1atm1.2Tche
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Kdm1aGt(RRK075)Byg/Kdm1aGt(RRK075)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Kdm1aGt(RRK075)Byg/Kdm1aGt(RRK075)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0011243 decreased fetal derived definitive erythrocyte cell number "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0020471 abnormal circadian behavior persistence "anomaly in the ability for an animal to retain a circadian behavior when time cues are removed" [MGI:smb]
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Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / complex / reaction
 ENSMUSG00000019777 Hdac2 / histone deacetylase 2 / Q92769*  / complex
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / reaction / complex
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000037896 Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*  / complex
 ENSMUSG00000029249 Rest / Q8VIG1 / RE1-silencing transcription factor / Q13127*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex






 

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