ENSDARG00000060679


Danio rerio

Features
Gene ID: ENSDARG00000060679
  
Biological name :kdm1a
  
Synonyms : kdm1a / lysine (K)-specific demethylase 1a
  
Possible biological names infered from orthology : lysine demethylase 1A / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341 / Q6ZQ88
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 28082441
Gene end: 28101989
  
Corresponding Affymetrix probe sets: Dr.2244.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000123983
Ensembl peptide - ENSDARP00000124296
Ensembl peptide - ENSDARP00000124977
Ensembl peptide - ENSDARP00000125081
Ensembl peptide - ENSDARP00000150698
Ensembl peptide - ENSDARP00000080193
NCBI entrez gene - 558450     See in Manteia.
RefSeq - NM_001242995
RefSeq Peptide - NP_001229924
swissprot - F6NIA2
swissprot - F8W3Z9
swissprot - F8W460
swissprot - F8W5I7
swissprot - F8W5U1
ZFIN ID - ZDB-GENE-030131-7828
Ensembl - ENSDARG00000060679
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KDM1AENSGALG00000033469Gallus gallus
 KDM1AENSG00000004487Homo sapiens
 Kdm1aENSMUSG00000036940Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smox / spermine oxidase / Q99K82* / Q9NWM0*ENSDARG0000003696716
paox1 / polyamine oxidase (exo-N4-amino) 1ENSDARG0000004340316
zgc:66484ENSDARG0000003047815
si:dkey-275b16.2 / PAOX* / Q8C0L6* / Q6QHF9* / polyamine oxidase* / Mus musculus polyamine oxidase (exo-N4-amino) (Paox), transcript variant 2, mRNA.*ENSDARG0000000338014
LO018020.1 / PAOX* / Q6QHF9* / polyamine oxidase*ENSDARG0000010959614


Protein motifs (from Interpro)
Interpro ID Name
 IPR002937  Amine oxidase
 IPR007526  SWIRM domain
 IPR009057  Homeobox-like domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017366  Histone lysine-specific demethylase
 IPR023753  FAD/NAD(P)-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0034720 histone H3-K4 demethylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1900052 regulation of retinoic acid biosynthetic process IGI
 biological_processGO:1903706 regulation of hemopoiesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood circulating cell decreased amount , abnormal
Show

 ZFA:0000008 brain brain morphology , abnormal
brain neuron decreased amount , abnormal
Show

 ZFA:0000094 blood island blood island decreased amount , abnormal
Show

 ZFA:0000445 optic tectum optic tectum morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism absent , abnormal
whole organism decreased life span , abnormal
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm increased distribution , abnormal
Show

 ZFA:0005023 hematopoietic system hematopoietic system decreased amount , abnormal
Show

 ZFA:0005042 posterior lateral plate mesoderm posterior lateral plate mesoderm decreased amount , abnormal
posterior lateral plate mesoderm increased amount , abnormal
Show

 ZFA:0005237 erythroblast erythroblast immature , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell increased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0009258 angioblastic mesenchymal cell angioblastic mesenchymal cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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