ENSMUSG00000019777


Mus musculus

Features
Gene ID: ENSMUSG00000019777
  
Biological name :Hdac2
  
Synonyms : Hdac2 / histone deacetylase 2
  
Possible biological names infered from orthology : Q92769
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B1
Gene start: 36974544
Gene end: 37001889
  
Corresponding Affymetrix probe sets: 10362520 (MoGene1.0st)   1439704_at (Mouse Genome 430 2.0 Array)   1445684_s_at (Mouse Genome 430 2.0 Array)   1449080_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019911
Ensembl peptide - ENSMUSP00000101149
NCBI entrez gene - 15182     See in Manteia.
MGI - MGI:1097691
RefSeq - XM_017313806
RefSeq - NM_008229
RefSeq - XM_006512555
RefSeq Peptide - NP_032255
swissprot - Q8BQ10
swissprot - A0A0R4J008
Ensembl - ENSMUSG00000019777
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HDAC2ENSGALG00000014991Gallus gallus
 HDAC2ENSG00000196591Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac1 / O09106 / Histone deacetylase 1 / Q13547*ENSMUSG0000002880085
Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*ENSMUSG0000006106284
Hdac3 / histone deacetylase 3 / O15379*ENSMUSG0000002445451
Hdac8 / Q8VH37 / Histone deacetylase 8 / Q9BY41*ENSMUSG0000006756732
Hdac11 / Q91WA3 / Histone deacetylase 11 / Q96DB2*ENSMUSG0000003424518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006344 maintenance of chromatin silencing IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032732 positive regulation of interleukin-1 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048149 behavioral response to ethanol IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0061000 negative regulation of dendritic spine development IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016580 Sin3 complex IEA
 cellular_componentGO:0016581 NuRD complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nlrp3M8Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3M8Btlr

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

Allelic Composition: Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe,Tg(Myh6-Hod)3Joe/?
Genetic Background: Not Specified

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001267 enlarged chest "wider diameter, or distended chest cavity" [J:18048]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Grin2ctm1Bnno/Grin2ctm1Bnno
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe,Tg(Myh6-Hod)3Joe/?
Genetic Background: Not Specified

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

Allelic Composition: Hdac2tm1.1Eno/Hdac2tm1.1Eno,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grin2ctm1Bnno/Grin2ctm1Bnno
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0003429 insensitivity to growth hormone "no growth response to exogenous growth hormone" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0004027 trisomy "presence of an extra chromosome in an otherwise diploid chromosome set" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0004093 diffuse Z lines "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Grin2ctm1Bnno/Grin2ctm1Bnno
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Hdac2tm1Lex/Hdac2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dazap1tm1.2Pyen/Dazap1tm1.2Pyen
Genetic Background: involves: 129S6/SvEvTac

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009309 small intestine adenocarcinoma "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Hdac2Gt(W035F03)Joe/Hdac2Gt(W035F03)Joe
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

Allelic Composition: Hdac2tm1Lex/Hdac2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

Allelic Composition: Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011963 abnormal total retina thickness "increased or decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Hdac2tm1Lex/Hdac2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0012050 decreased susceptilbility to retinal ischemic injury "decreased frequency or less severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina" [MGI:csmith]
Show

Allelic Composition: Hdac2tm1Lex/Hdac2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0012404 abnormal nail color "a variation in an expected nail color, that may be due to infection, inflammation or other causes" [MGI:smb]
Show

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000029249 Rest / Q8VIG1 / RE1-silencing transcription factor / Q13127*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex
 ENSMUSG00000037896 Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*  / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr