ENSMUSG00000034245


Mus musculus

Features
Gene ID: ENSMUSG00000034245
  
Biological name :Hdac11
  
Synonyms : Hdac11 / Histone deacetylase 11 / Q91WA3
  
Possible biological names infered from orthology : Q96DB2
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 91156665
Gene end: 91174692
  
Corresponding Affymetrix probe sets: 10540075 (MoGene1.0st)   1451229_at (Mouse Genome 430 2.0 Array)   1454803_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145014
Ensembl peptide - ENSMUSP00000043828
Ensembl peptide - ENSMUSP00000120923
Ensembl peptide - ENSMUSP00000121624
NCBI entrez gene - 232232     See in Manteia.
MGI - MGI:2385252
RefSeq - XM_017321536
RefSeq - NM_144919
RefSeq - XM_017321535
RefSeq Peptide - NP_659168
swissprot - A0A0N4SVA2
swissprot - Q543U1
swissprot - Q91WA3
swissprot - F6UL83
swissprot - D3Z2G7
Ensembl - ENSMUSG00000034245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac11ENSDARG00000087573Danio rerio
 HDAC11ENSGALG00000005092Gallus gallus
 HDAC11ENSG00000163517Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*ENSMUSG0000006106226
Hdac1 / O09106 / Histone deacetylase 1 / Q13547*ENSMUSG0000002880026
Hdac2 / histone deacetylase 2 / Q92769*ENSMUSG0000001977726
Hdac3 / histone deacetylase 3 / O15379*ENSMUSG0000002445422
Hdac8 / Q8VH37 / Histone deacetylase 8 / Q9BY41*ENSMUSG0000006756722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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