ENSMUSG00000067567


Mus musculus

Features
Gene ID: ENSMUSG00000067567
  
Biological name :Hdac8
  
Synonyms : Hdac8 / Histone deacetylase 8 / Q8VH37
  
Possible biological names infered from orthology : Q9BY41
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 102284639
Gene end: 102505359
  
Corresponding Affymetrix probe sets: 10606088 (MoGene1.0st)   1428933_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085226
Ensembl peptide - ENSMUSP00000138805
NCBI entrez gene - 70315     See in Manteia.
MGI - MGI:1917565
RefSeq - XM_011247671
RefSeq - NM_027382
RefSeq - XM_006528275
RefSeq - XM_006528276
RefSeq - XM_011247670
RefSeq Peptide - NP_081658
swissprot - Q8VH37
swissprot - S4R2V6
Ensembl - ENSMUSG00000067567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac8ENSDARG00000003021Danio rerio
 HDAC8ENSGALG00000004825Gallus gallus
 HDAC8ENSG00000147099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hdac1 / O09106 / Histone deacetylase 1 / Q13547*ENSMUSG0000002880043
Hdac2 / histone deacetylase 2 / Q92769*ENSMUSG0000001977742
Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*ENSMUSG0000006106242
Hdac3 / histone deacetylase 3 / O15379*ENSMUSG0000002445440
Hdac11 / Q91WA3 / Histone deacetylase 11 / Q96DB2*ENSMUSG0000003424521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032204 regulation of telomere maintenance IEA
 biological_processGO:0035984 cellular response to trichostatin A IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071922 regulation of cohesin loading IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 biological_processGO:2000616 negative regulation of histone H3-K9 acetylation IEA
 cellular_componentGO:0000118 histone deacetylase complex TAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HDACs deacetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Gys2tm1a(KOMP)Wtsi/Gys2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Gys2tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gys2tm1a(KOMP)Wtsi/Gys2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Gys2tm1a(KOMP)Wtsi/Wtsi

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.1Eno/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.1Eno/Y,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Hdac8tm1.1Eno/Y,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

Allelic Composition: Hdac8tm1.1Eno/Y,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0004378 frontal bone foramen "presence of a hole in the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.1Eno/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1

 MP:0008276 failure of intramembranous bone ossification "failure to initiate or a block in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.1Eno/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Atrtm1Twgl/Atrtm1Twgl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac8tm1.2Eno/Hdac8tm1.2Eno
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.2Eno/Hdac8+
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Hdac8tm1.1Eno/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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