ENSMUSG00000060743


Mus musculus

Features
Gene ID: ENSMUSG00000060743
  
Biological name :H3f3a
  
Synonyms : H3f3a / Histone H3.3 / P84244
  
Possible biological names infered from orthology : H3 histone family member 3A / P84243
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H4
Gene start: 180800832
Gene end: 180813943
  
Corresponding Affymetrix probe sets: 10360679 (MoGene1.0st)   10411776 (MoGene1.0st)   10412378 (MoGene1.0st)   10540507 (MoGene1.0st)   1423262_a_at (Mouse Genome 430 2.0 Array)   1423263_at (Mouse Genome 430 2.0 Array)   1434127_a_at (Mouse Genome 430 2.0 Array)   1442087_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124040
Ensembl peptide - ENSMUSP00000125754
Ensembl peptide - ENSMUSP00000125104
Ensembl peptide - ENSMUSP00000124509
Ensembl peptide - ENSMUSP00000079816
Ensembl peptide - ENSMUSP00000123946
NCBI entrez gene - 15078     See in Manteia.
MGI - MGI:1097686
RefSeq - NM_008210
RefSeq Peptide - NP_032236
swissprot - F8WI35
swissprot - E0CZ27
swissprot - P84244
swissprot - E0CYR7
swissprot - E0CYN1
Ensembl - ENSMUSG00000060743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h3f3dENSDARG00000045248Danio rerio
 H3F3CENSGALG00000020078Gallus gallus
 H3F3AENSG00000163041Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H3f3b / P84244 / Histone H3.3 ENSMUSG00000016559100
P84228 / Hist1h3f / Histone H3.2 ENSMUSG0000010021097
P84228 / Hist2h3c2 / Histone H3.2 / Q71DI3* / HIST2H3D* / histone cluster 2 H3 family member d*ENSMUSG0000008105897
P84228 / Hist2h3c1 / Histone H3.2 ENSMUSG0000009376997
P84228 / Hist1h3e / Histone H3.2 ENSMUSG0000006927397
P84228 / Hist1h3c / Histone H3.2 / Q71DI3* / HIST2H3D* / histone cluster 2 H3 family member d*ENSMUSG0000006931097
P84228 / Hist2h3b / Histone H3.2 / Q71DI3* / HIST2H3A* / histone cluster 2 H3 family member a*ENSMUSG0000007440397
P84228 / Hist1h3d / Histone H3.2 ENSMUSG0000009958397
P84228 / Hist1h3b / Histone H3.2 ENSMUSG0000006926797
P68433 / Hist1h3i / Histone H3.1 ENSMUSG0000010197296
P68433 / Hist1h3g / Histone H3.1 ENSMUSG0000009951796
P68433 / Hist1h3a / Histone H3.1 / P68431* / HIST1H3F* / histone cluster 1 H3 family member f*ENSMUSG0000006926596
P68433 / Hist1h3h / Histone H3.1 / P68431* / HIST1H3B* / histone cluster 1 H3 family member b*ENSMUSG0000010135596
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2ap / Histone H2A type 1-B / P04908* / HIST1H2AE* / histone cluster 1 H2A family member e*ENSMUSG0000009477720
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2ao / Histone H2A type 1-B / P04908* / HIST1H2AE* / histone cluster 1 H2A family member e*ENSMUSG0000009424820
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2an / Histone H2A type 1-B ENSMUSG0000006930920
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2ag / Histone H2A type 1-B ENSMUSG0000006930120
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2ai / Histone H2A type 1-B ENSMUSG0000007151620
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2ae / Histone H2A type 1-B ENSMUSG0000006927220
C0HKE2 / C0HKE3 / C0HKE4 / C0HKE5 / C0HKE6 / C0HKE7 / C0HKE8 / C0HKE9 / C0HKE1 / Hist1h2ad / Histone H2A type 1-B ENSMUSG0000007147820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000164  Histone H3/CENP-A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0006334 nucleosome assembly IBA
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IEA
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0008283 cell proliferation IGI
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031508 pericentric heterochromatin assembly IGI
 biological_processGO:0031509 telomeric heterochromatin assembly IGI
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042692 muscle cell differentiation IGI
 biological_processGO:0048477 oogenesis IGI
 biological_processGO:0090230 regulation of centromere complex assembly IMP
 biological_processGO:1902340 negative regulation of chromosome condensation IGI
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISO
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000788 nuclear nucleosome ISO
 cellular_componentGO:0001740 Barr body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0031492 nucleosomal DNA binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tbx1tm2Bem/Tbx1tm2Bem
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: H3f3atm1.2Mnn/H3f3atm1.2Mnn
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129S4/SvJaeSor

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2Bem/Tbx1tm2Bem
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000708 Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*  / reaction
 ENSMUSG00000000730 Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*  / complex / reaction
 ENSMUSG00000001228 Uhrf1 / Q8VDF2 / ubiquitin-like, containing PHD and RING finger domains, 1 / Q96T88* / ubiquitin like with PHD and ring finger domains 1*  / complex / reaction
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / reaction / complex
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000004099 Dnmt1 / P13864 / DNA (cytosine-5)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / reaction / complex
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / reaction / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / reaction / complex
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / complex / reaction
 ENSMUSG00000013787 Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*  / reaction
 ENSMUSG00000026398 Nr5a2 / P45448 / Nuclear receptor subfamily 5 group A member 2 / O00482*  / complex
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / complex
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000030888 Rrp8 / Q9DB85 / Ribosomal RNA-processing protein 8 / O43159* / ribosomal RNA processing 8*  / reaction / complex
 ENSMUSG00000034748 Sirt6 / P59941 / sirtuin 6 / Q8N6T7*  / complex / reaction
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / reaction / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000032577 Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*  / reaction
 ENSMUSG00000042557 Sin3a / Q60520 / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q96ST3* / SIN3 transcription regulator family member A*  / complex
 ENSMUSG00000036893 Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*  / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex
 ENSMUSG00000037876 Jmjd1c / Q69ZK6 / Probable JmjC domain-containing histone demethylation protein 2C / Q15652* / jumonji domain containing 1C*  / reaction
 ENSMUSG00000027478 Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / reaction / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / reaction / complex
 ENSMUSG00000052056 Zfp217 / zinc finger protein 217 / O75362* / ZNF217*  / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000027678 Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex
 ENSMUSG00000018476 Kdm6b / Q5NCY0 / Lysine-specific demethylase 6B / O15054* / lysine demethylase 6B*  / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000024513 Mbd2 / Q9Z2E1 / Methyl-CpG-binding domain protein 2 / Q9UBB5*  / reaction / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060445 Sycp2 / Q9CUU3 / Synaptonemal complex protein 2 / Q9BX26*  / complex
 ENSMUSG00000018973 Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*  / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex / reaction
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex / reaction
 ENSMUSG00000037369 Kdm6a / O70546 / Lysine-specific demethylase 6A / O15550* / lysine demethylase 6A*  / complex
 ENSMUSG00000049300 Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*  / complex
 ENSMUSG00000006705 O70477 / Pknox1 / Homeobox protein PKNOX1 / P55347* / PBX/knotted 1 homeobox 1*  / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / complex / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000029836 Cbx3 / chromobox protein homolog 3 / Q13185* / chromobox 3*  / complex
 ENSMUSG00000052534 Pbx1 / P41778 / Pre-B-cell leukemia transcription factor 1 / P40424* / PBX homeobox 1*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000028397 Kdm4c / Q8VCD7 / Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript variant 3, mRNA. / Q9H3R0* / lysine demethylase 4C*  / reaction / complex
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction
 ENSMUSG00000041530 Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*  / reaction / complex
 ENSMUSG00000009575 Cbx5 / Q61686 / Mus musculus chromobox 5 (Cbx5), transcript variant 4, mRNA. / P45973* / chromobox 5*  / reaction / complex
 ENSMUSG00000039231 O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*  / reaction / complex
 ENSMUSG00000051977 Prdm9 / Q96EQ9 / PR domain containing 9 / Q9NQV7* / PR/SET domain 9*  / reaction






 

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