ENSMUSG00000027478


Mus musculus

Features
Gene ID: ENSMUSG00000027478
  
Biological name :Dnmt3b
  
Synonyms : DNA (cytosine-5)-methyltransferase 3B / Dnmt3b / O88509
  
Possible biological names infered from orthology : DNA methyltransferase 3 beta / Q9UBC3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 153649450
Gene end: 153687730
  
Corresponding Affymetrix probe sets: 10477325 (MoGene1.0st)   1418351_a_at (Mouse Genome 430 2.0 Array)   1442655_at (Mouse Genome 430 2.0 Array)   1449052_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051830
Ensembl peptide - ENSMUSP00000072761
Ensembl peptide - ENSMUSP00000080334
Ensembl peptide - ENSMUSP00000086370
Ensembl peptide - ENSMUSP00000099439
Ensembl peptide - ENSMUSP00000099440
Ensembl peptide - ENSMUSP00000105393
Ensembl peptide - ENSMUSP00000105394
Ensembl peptide - ENSMUSP00000105395
Ensembl peptide - ENSMUSP00000105396
NCBI entrez gene - 13436     See in Manteia.
MGI - MGI:1261819
RefSeq - XM_006498689
RefSeq - NM_001003960
RefSeq - NM_001003961
RefSeq - NM_001003963
RefSeq - NM_001122997
RefSeq - NM_001271744
RefSeq - NM_001271745
RefSeq - NM_001271746
RefSeq - NM_001271747
RefSeq - NM_010068
RefSeq - XM_006498682
RefSeq - XM_006498683
RefSeq - XM_006498684
RefSeq - XM_006498685
RefSeq - XM_006498686
RefSeq - XM_006498687
RefSeq - XM_006498688
RefSeq Peptide - NP_001258676
RefSeq Peptide - NP_001258674
RefSeq Peptide - NP_001258675
RefSeq Peptide - NP_034198
RefSeq Peptide - NP_001003960
RefSeq Peptide - NP_001003961
RefSeq Peptide - NP_001003963
RefSeq Peptide - NP_001116469
RefSeq Peptide - NP_001258673
swissprot - O88509
swissprot - Q3KR45
swissprot - Q541E5
Ensembl - ENSMUSG00000027478
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnmt3bb.1ENSDARG00000036791Danio rerio
 DNMT3BENSGALG00000041461Gallus gallus
 DNMT3BENSG00000088305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnmt3c / DNMT3B* / Q9UBC3* / DNA methyltransferase 3 beta*ENSMUSG0000008207972
Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*ENSMUSG0000002066148
Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*ENSMUSG0000000073016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001525  C-5 cytosine methyltransferase
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR018117  DNA methylase, C-5 cytosine-specific, active site
 IPR025766  ADD domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030488  DNA (cytosine-5)-methyltransferase 3B, ADD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0006346 methylation-dependent chromatin silencing IGI
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0031503 protein-containing complex localization IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043045 DNA methylation involved in embryo development IEP
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation ISO
 biological_processGO:0051573 negative regulation of histone H3-K9 methylation ISO
 biological_processGO:0060821 inactivation of X chromosome by DNA methylation IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0090116 C-5 methylation of cytosine IDA
 cellular_componentGO:0000775 chromosome, centromeric region IDA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0003886 DNA (cytosine-5-)-methyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0009008 DNA-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IDA
 molecular_functionGO:0051719 DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates TAS


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
SUMOylation of DNA methylation proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Dnmt3atm3.2Enl/Dnmt3atm3.2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Dnmt3atm3.2Enl/Dnmt3atm3.2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0004375 enlarged frontal bone "increased size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004379 wide frontal bone "increased width of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004386 enlarged interparietal bone "increased size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

Allelic Composition: Dnmt3btm1.1Ics/Dnmt3btm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnmt3btm1.1Ics/Dnmt3btm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

Allelic Composition: Dnmt3btm5.2Enl/Dnmt3btm5.2Enl
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012167 abnormal epigenetic regulation of gene expression "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dnmt3bMommeD14/Dnmt3btm1Enl,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000000730 Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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