ENSMUSG00000020661


Mus musculus

Features
Gene ID: ENSMUSG00000020661
  
Biological name :Dnmt3a
  
Synonyms : DNA (cytosine-5)-methyltransferase 3A / Dnmt3a / O88508
  
Possible biological names infered from orthology : DNA methyltransferase 3 alpha / Q9Y6K1
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 3806007
Gene end: 3914443
  
Corresponding Affymetrix probe sets: 10394209 (MoGene1.0st)   1423063_at (Mouse Genome 430 2.0 Array)   1423064_at (Mouse Genome 430 2.0 Array)   1423065_at (Mouse Genome 430 2.0 Array)   1423066_at (Mouse Genome 430 2.0 Array)   1460324_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134689
Ensembl peptide - ENSMUSP00000020991
Ensembl peptide - ENSMUSP00000106817
Ensembl peptide - ENSMUSP00000133501
Ensembl peptide - ENSMUSP00000133543
Ensembl peptide - ENSMUSP00000133567
Ensembl peptide - ENSMUSP00000133869
Ensembl peptide - ENSMUSP00000133938
Ensembl peptide - ENSMUSP00000134009
Ensembl peptide - ENSMUSP00000134480
Ensembl peptide - ENSMUSP00000134492
Ensembl peptide - ENSMUSP00000134496
Ensembl peptide - ENSMUSP00000134529
Ensembl peptide - ENSMUSP00000134567
Ensembl peptide - ENSMUSP00000134632
NCBI entrez gene - 13435     See in Manteia.
MGI - MGI:1261827
RefSeq - XM_006514956
RefSeq - NM_001271753
RefSeq - NM_007872
RefSeq - NM_153743
RefSeq - XM_006514953
RefSeq Peptide - NP_001258682
RefSeq Peptide - NP_031898
RefSeq Peptide - NP_714965
swissprot - G3UZU0
swissprot - G3UZY8
swissprot - G3UX63
swissprot - O88508
swissprot - G3UX07
swissprot - G3UXY2
swissprot - G3UY43
swissprot - G3UZF8
swissprot - G3UZH2
swissprot - G3UZG8
swissprot - G3UZK0
swissprot - G3UZN5
Ensembl - ENSMUSG00000020661
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnmt3aaENSDARG00000005394Danio rerio
 dnmt3abENSDARG00000015566Danio rerio
 DNMT3AENSGALG00000041454Gallus gallus
 DNMT3AENSG00000119772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*ENSMUSG0000002747846
Dnmt3c / DNMT3B* / Q9UBC3* / DNA methyltransferase 3 beta*ENSMUSG0000008207939
Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*ENSMUSG0000000073015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001525  C-5 cytosine methyltransferase
 IPR018117  DNA methylase, C-5 cytosine-specific, active site
 IPR025766  ADD domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030487  DNA (cytosine-5)-methyltransferase 3A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006306 DNA methylation ISO
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006346 methylation-dependent chromatin silencing IGI
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032776 DNA methylation on cytosine IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043045 DNA methylation involved in embryo development IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090116 C-5 methylation of cytosine IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 cellular_componentGO:0000775 chromosome, centromeric region IDA
 cellular_componentGO:0000791 euchromatin ISO
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016363 nuclear matrix ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003886 DNA (cytosine-5-)-methyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity TAS
 molecular_functionGO:0009008 DNA-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051719 DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates TAS


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
RMTs methylate histone arginines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1(KOMP)Wtsi/Dnase1l2tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1(KOMP)Wtsi/Wtsi

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Dnase1l2tm1(KOMP)Wtsi/Dnase1l2tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1(KOMP)Wtsi/Wtsi

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Dnase1l2tm1(KOMP)Wtsi/Dnase1l2tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1(KOMP)Wtsi/Wtsi

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

Allelic Composition: Dnmt3atm3.2Enl/Dnmt3atm3.2Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

Allelic Composition: Dnmt3atm3.2Enl/Dnmt3atm3.2Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fmodtm1Aol/Fmodtm1Aol,Lumtm1Chak/Lumtm1Chak
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Cdh23v-J/Cdh23v-J
Genetic Background: B6.C-H2-Kbm1/ByJ

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase1l2tm1(KOMP)Wtsi/Dnase1l2tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1(KOMP)Wtsi/Wtsi

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Dnase1l2tm1(KOMP)Wtsi/Dnase1l2tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1(KOMP)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Dnmt3atm1Jae/Dnmt3atm1Jae,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Dnase1l2tm1(KOMP)Wtsi/Dnase1l2tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1(KOMP)Wtsi/Wtsi

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ppargtm2Avp/Ppargtm2Avp
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000057236 Rbbp4 / Q60972 / Histone-binding protein RBBP4 / Q09028* / RB binding protein 4, chromatin remodeling factor*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000030619 Eed / Q921E6 / Polycomb protein EED / O75530* / embryonic ectoderm development*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000000730 Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*  / complex
 ENSMUSG00000020661 Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*  / complex
 ENSMUSG00000031353 Rbbp7 / Q60973 / retinoblastoma binding protein 7, chromatin remodeling factor / Q16576* / RB binding protein 7, chromatin remodeling factor*  / reaction / complex
 ENSMUSG00000029687 Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSMUSG00000017548 Suz12 / Q80U70 / Polycomb protein Suz12 / Q15022* / SUZ12 polycomb repressive complex 2 subunit*  / complex / reaction






 

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