ENSMUSG00000082079


Mus musculus

Features
Gene ID: ENSMUSG00000082079
  
Biological name :Dnmt3c
  
Synonyms : Dnmt3c
  
Possible biological names infered from orthology : DNA methyltransferase 3 beta / DNMT3B / Q9UBC3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 153696652
Gene end: 153729907
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSMUSP00000153622
MGI - MGI:3649996
swissprot - A0A286YDX7
Ensembl - ENSMUSG00000082079
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnmt3bb.1ENSDARG00000036791Danio rerio
 DNMT3BENSGALG00000041461Gallus gallus
 DNMT3BENSG00000088305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnmt3b / O88509 / DNA (cytosine-5)-methyltransferase 3B / Q9UBC3* / DNA methyltransferase 3 beta*ENSMUSG0000002747883
Dnmt3a / O88508 / DNA (cytosine-5)-methyltransferase 3A / Q9Y6K1* / DNA methyltransferase 3 alpha*ENSMUSG0000002066148
Dnmt3l / Q9CWR8 / DNA (cytosine-5)-methyltransferase 3-like / Q9UJW3* / FP565260.4* / DNA methyltransferase 3 like*ENSMUSG0000000073018


Protein motifs (from Interpro)
Interpro ID Name
 IPR001525  C-5 cytosine methyltransferase
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR018117  DNA methylase, C-5 cytosine-specific, active site
 IPR025766  ADD domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032259 methylation IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
SUMOylation of DNA methylation proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

Allelic Composition: Dnmt3cem1Sky/Dnmt3crahu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

Allelic Composition: Dnmt3cem4Sky/Dnmt3crahu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

Allelic Composition: Dnmt3cem2Sky/Dnmt3cem2Sky
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Dnmt3cem2Sky/Dnmt3cem3Sky
Genetic Background: involves: C57BL/6 * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

Allelic Composition: Dnmt3cem4Sky/Dnmt3crahu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

Allelic Composition: Dnmt3cem2Sky/Dnmt3cem3Sky
Genetic Background: involves: C57BL/6 * CBA

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

 MP:0008878 abnormal DNA methylation during gametogenesis "any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established" [GO:0043046]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Olfr151tm42(Mc4r)Mom/Olfr151tm42(Mc4r)Mom
Genetic Background: B6;129P2-Olfr151tm42(Mc4r)Mom/MomJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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