Manteia

ENSGALG00000041461

Gallus gallus

Features

Gene ID:	ENSGALG00000041461

Biological name :	DNMT3B

Synonyms :	DNA methyltransferase 3 beta / DNMT3B

Possible biological names infered from orthology :	DNA (cytosine-5)-methyltransferase 3B / Dnmt3c / O88509 / Q9UBC3

Species:	Gallus gallus

Chr. number:	20
Strand:	1
Band:
Gene start:	10452242
Gene end:	10464723

Corresponding Affymetrix probe sets:	Gga.8354.1.S1_at (Chicken Array) GgaAffx.4121.1.S1_s_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000052985 NCBI entrez gene - 419287 See in Manteia. RefSeq - XM_015296402 RefSeq - NM_001024828 RefSeq - XM_015296400 RefSeq - XM_015296401 RefSeq - XM_015296399 RefSeq Peptide - NP_001019999 swissprot - A0A1D5PJJ1 Ensembl - ENSGALG00000041461

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
DNMT3A / DNA (cytosine-5)-methyltransferase 3A / O88508* / Q9Y6K1* / DNA methyltransferase 3 alpha*	ENSGALG00000041454	42

Protein motifs (from Interpro)

Interpro ID	Name
IPR000313	PWWP domain
IPR011011	Zinc finger, FYVE/PHD-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR018117	DNA methylase, C-5 cytosine-specific, active site
IPR025766	ADD domain
IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
IPR030488	DNA (cytosine-5)-methyltransferase 3B, ADD domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006306	DNA methylation	IEA
biological_process	GO:0010468	regulation of gene expression	IEA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0051571	positive regulation of histone H3-K4 methylation	IEA
biological_process	GO:0051573	negative regulation of histone H3-K9 methylation	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0003714	transcription corepressor activity	IEA
molecular_function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IEA
molecular_function	GO:0008168	methyltransferase activity	IEA
molecular_function	GO:0009008	DNA-methyltransferase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

PRC2 methylates histones and DNA

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000008435	SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*	/ complex / reaction
ENSGALG00000020078	H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...	/ complex / reaction
ENSGALG00000043399	EZH2 / enhancer of zeste 2 polycomb repressive complex 2 subunit / Q15910* / Q61188* / Histone-lysine N-methyltransferase EZH2 *	/ complex / reaction
ENSGALG00000042491	P62801 / Histone H4	/ complex / reaction
ENSGALG00000043062	P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*	/ complex / reaction
ENSGALG00000014060	EED / Q5ZKH3 / Polycomb protein EED / O75530* / Q921E6* / embryonic ectoderm development*	/ reaction / complex
ENSGALG00000006428	UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr