ENSDARG00000036791


Danio rerio

Features
Gene ID: ENSDARG00000036791
  
Biological name :dnmt3bb.1
  
Synonyms : DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1 / dnmt3bb.1
  
Possible biological names infered from orthology : DNA (cytosine-5)-methyltransferase 3B / DNA methyltransferase 3 beta / DNMT3B / Dnmt3c / O88509 / Q9UBC3
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 17011454
Gene end: 17101360
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000053417
NCBI entrez gene - 317744     See in Manteia.
RefSeq - NM_001025450
RefSeq Peptide - NP_001020621
swissprot - Q588C6
ZFIN ID - ZDB-GENE-050314-1
Ensembl - ENSDARG00000036791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DNMT3BENSGALG00000041461Gallus gallus
 DNMT3BENSG00000088305Homo sapiens
 Dnmt3bENSMUSG00000027478Mus musculus
 Dnmt3cENSMUSG00000082079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dnmt3ab / DNA (cytosine-5-)-methyltransferase 3 alpha b / Q9Y6K1* / DNMT3A* / O88508* / DNA methyltransferase 3 alpha* / DNA (cytosine-5)-methyltransferase 3A *ENSDARG0000001556651
dnmt3aa / DNA (cytosine-5-)-methyltransferase 3 alpha a / Q9Y6K1* / DNMT3A* / O88508* / DNA methyltransferase 3 alpha* / DNA (cytosine-5)-methyltransferase 3A *ENSDARG0000000539450
dnmt3ba / DNA (cytosine-5-)-methyltransferase 3 beta, duplicate aENSDARG0000005240248
dnmt3bb.2 / DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2ENSDARG0000005783043
dnmt3bb.3 / DNA (cytosine-5-)-methyltransferase beta, duplicate b.3ENSDARG0000005786343


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001525  C-5 cytosine methyltransferase
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR018117  DNA methylase, C-5 cytosine-specific, active site
 IPR025766  ADD domain
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR030488  DNA (cytosine-5)-methyltransferase 3B, ADD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0010424 DNA methylation on cytosine within a CG sequence IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0009008 DNA-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
SUMOylation of DNA methylation proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
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 ZFA:0000669 head kidney head kidney hematopoietic cell decreased amount , abnormal
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 ZFA:0001078 thymus thymus decreased amount , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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 ZFA:0009044 blood cell blood cell DNA methylation decreased occurrence , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte malformed , abnormal
nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009324 myeloid cell myeloid cell decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell shape , abnormal
hematopoietic multipotent progenitor cell increased amount , abnormal
hematopoietic multipotent progenitor cell malformed , abnormal
hematopoietic multipotent progenitor cell decreased amount , abnormal
hematopoietic multipotent progenitor cell DNA methylation decreased occurrence , abnormal
hematopoietic multipotent progenitor cell apoptotic , abnormal
hematopoietic multipotent progenitor cell apoptotic process increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / reaction / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000098924 suz12b / B0R1D5 / SUZ12 polycomb repressive complex 2b subunit / SUZ12* / Q80U70* / Q15022* / Polycomb protein Suz12 * / SUZ12 polycomb repressive complex 2 subunit*  / reaction / complex
 ENSDARG00000105345 zgc:173552  / complex / reaction
 ENSDARG00000099640 eed / Q566T0 / embryonic ectoderm development / O75530* / Q921E6* / Polycomb protein EED *  / reaction / complex






 

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