ENSGALG00000008435


Gallus gallus

Features
Gene ID: ENSGALG00000008435
  
Biological name :SUMO1
  
Synonyms : Q8QGH2 / Small ubiquitin-related modifier 1 / SUMO1
  
Possible biological names infered from orthology : P63165 / P63166 / small ubiquitin-like modifier 1
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 11816558
Gene end: 11828007
  
Corresponding Affymetrix probe sets: Gga.8466.1.S1_s_at (Chicken Array)   GgaAffx.11573.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013729
NCBI entrez gene - 373930     See in Manteia.
RefSeq - XM_015289363
RefSeq - NM_204135
RefSeq - XM_015289365
RefSeq Peptide - NP_989466
swissprot - Q8QGH2
Ensembl - ENSGALG00000008435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sumo1ENSDARG00000044267Danio rerio
 SUMO1ENSG00000116030Homo sapiens
 Sumo1ENSMUSG00000026021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SUMO3 / small ubiquitin-related modifier 3 precursor / P55854* / Q9Z172* / small ubiquitin-like modifier 3*ENSGALG0000003278350
SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*ENSGALG0000000797138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016925 protein sumoylation ISS
 biological_processGO:0030578 PML body organization IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045759 negative regulation of action potential IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:0090204 protein localization to nuclear pore IEA
 biological_processGO:1901896 positive regulation of calcium-transporting ATPase activity IEA
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IEA
 cellular_componentGO:0001741 XY body IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0031510 SUMO activating enzyme complex IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0097165 nuclear stress granule IEA
 molecular_functionGO:0001222 transcription corepressor binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0031386 protein tag IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0044388 small protein activating enzyme binding IEA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction / complex
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / complex / reaction
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / complex / reaction
 ENSGALG00000008545 SENP5 / SUMO1/sentrin specific peptidase 5 / Q6NXL6* / Q96HI0* / Sentrin-specific protease 5 *  / reaction
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex
 ENSGALG00000007690 TFAP2C / transcription factor AP-2 gamma / Q61312* / Q92754*  / reaction / complex
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000039942 CTBP1 / C-terminal-binding protein 1 / O88712* / Q13363*  / complex / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000001644 SIN3A / SIN3 transcription regulator family member A / Q60520* / Q96ST3* / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000016617 NCOA1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction / complex
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSGALG00000036214 PARK7 / protein/nucleic acid deglycase DJ-1 / Q99497* / Q99LX0* / Parkinsonism associated deglycase*  / complex / reaction
 ENSGALG00000014859 P52739* / Q8K3J5* / Zfp131* / ZNF131* / zinc finger protein 131*  / complex / reaction
 ENSGALG00000039583 MITF / microphthalmia-associated transcription factor / O75030* / Q08874* / melanogenesis associated transcription factor*  / complex / reaction
 ENSGALG00000032992 NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*  / complex / reaction
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSGALG00000001080 NR5A1 / steroidogenic factor 1 / P33242* / Q13285* / nuclear receptor subfamily 5 group A member 1*  / reaction / complex
 ENSGALG00000015681 NRIP1 / nuclear receptor interacting protein 1 / P48552* / Q8CBD1* / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transcript variant 2, mRNA.*  / reaction / complex
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / complex / reaction
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / reaction / complex
 ENSGALG00000011254 SATB1 / SATB homeobox 1 / Q01826* / Q60611* / Mus musculus special AT-rich sequence binding protein 1 (Satb1), transcript variant 5, mRNA.*  / reaction / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / reaction / complex
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / complex / reaction
 ENSGALG00000029282 FOXL2 / forkhead box L2 / O88470* / P58012* / Forkhead box protein L2 *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction / complex
 ENSGALG00000041461 DNMT3B / DNA methyltransferase 3 beta / Dnmt3c* / Q9UBC3* / O88509* / DNA (cytosine-5)-methyltransferase 3B *  / complex / reaction
 ENSGALG00000020523 TOPORS / TOP1 binding arginine/serine rich protein / Q80Z37* / Q9NS56* / E3 ubiquitin-protein ligase Topors *  / reaction / complex
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / complex / reaction
 ENSGALG00000013365 SAFB* / SAFB2* / Q80YR5* / D3YXK2* / Q14151* / Q15424* / scaffold attachment factor B* / scaffold attachment factor B2* / Scaffold attachment factor B1 *  / reaction / complex
 ENSGALG00000031796 SP3 / Q90WR8 / Transcription factor Sp3 / Q02447* / O70494* / Sp3 transcription factor*  / reaction / complex
 ENSGALG00000011294 THRB / P68306 / Thyroid hormone receptor beta / P10828* / P37242*  / complex / reaction
 ENSGALG00000005006 UBA2 / SUMO-activating enzyme subunit 2 / Q9UBT2* / Q9Z1F9* / ubiquitin like modifier activating enzyme 2*  / complex / reaction
 ENSGALG00000040909 WRN / Werner syndrome RecQ like helicase / O09053* / Q14191*  / complex / reaction
 ENSGALG00000011300 TOP2B / DNA topoisomerase 2-beta / Q02880* / Q64511* / DNA topoisomerase II beta*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000003922 TOP2A / DNA topoisomerase 2-alpha / P11388* / Q01320* / DNA topoisomerase II alpha*  / complex / reaction
 ENSGALG00000008482 STAG2 / stromal antigen 2 / O35638* / Q8N3U4*  / complex
 ENSGALG00000011966 RANGAP1 / ran GTPase-activating protein 1 / P46060* / P46061*  / complex
 ENSGALG00000001948 SAFB* / SAFB2* / Q80YR5* / D3YXK2* / Q14151* / Q15424* / scaffold attachment factor B* / scaffold attachment factor B2* / Scaffold attachment factor B1 *  / reaction / complex
 ENSGALG00000039171 RAD52 / DNA repair protein RAD52 homolog isoform 2 / P43351* / P43352* / RAD52 homolog, DNA repair protein*  / complex / reaction
 ENSGALG00000041267 BMI1 / Q5SDR3 / Polycomb complex protein BMI-1 / P25916* / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / BMI1 proto-oncogene, polycomb ring finger*  / complex
 ENSGALG00000012484 RIF1 / E1C2U2 / Telomere-associated protein RIF1 / Q6PR54* / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSGALG00000004288 HDAC4 / P83038 / Histone deacetylase 4 / P56524* / Q6NZM9*  / reaction / complex
 ENSGALG00000007970 PIAS1 / E3 SUMO-protein ligase PIAS1 / O75925* / O88907* / protein inhibitor of activated STAT 1*  / complex / reaction
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000037360 DDX17 / DEAD-box helicase 17 / Q501J6* / Q92841* / Probable ATP-dependent RNA helicase DDX17 *  / reaction / complex
 ENSGALG00000031457 TDG / thymine DNA glycosylase / P56581* / Q13569* / Mus musculus thymine DNA glycosylase (Tdg), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000005695 CHEK2 / checkpoint kinase 2 / O96017* / Q9Z265* / Serine/threonine-protein kinase Chk2 *  / reaction / complex
 ENSGALG00000015620 XRCC4 / X-ray repair cross complementing 4 / Q13426* / X-ray repair complementing defective repair in Chinese hamster cells 4*  / reaction / complex
 ENSGALG00000010035 NR3C2 / mineralocorticoid receptor / P08235* / nuclear receptor subfamily 3 group C member 2*  / reaction / complex
 ENSGALG00000011594 NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *  / complex / reaction
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / reaction / complex
 ENSGALG00000031128 SENP2 / SUMO1/sentrin/SMT3 specific peptidase 2 / Gm7275* / Gm5407* / Gm5415* / Q91ZX6* / Q9HC62* / AF366264* / 4930444G20Rik* / cDNA sequence AF366264* / RIKEN cDNA 4930444G20 gene* / Mus ...  / reaction
 ENSGALG00000041470 PPARA / peroxisome proliferator-activated receptor alpha / P23204* / Q07869*  / complex / reaction
 ENSGALG00000045534 PML* / P29590* / Q60953* / Protein PML * / promyelocytic leukemia*  / complex / reaction






 

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