ENSGALG00000007970


Gallus gallus

Features
Gene ID: ENSGALG00000007970
  
Biological name :PIAS1
  
Synonyms : E3 SUMO-protein ligase PIAS1 / PIAS1
  
Possible biological names infered from orthology : O75925 / O88907 / protein inhibitor of activated STAT 1
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 19107954
Gene end: 19156499
  
Corresponding Affymetrix probe sets: GgaAffx.4990.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012927
Ensembl peptide - ENSGALP00000046656
Ensembl peptide - ENSGALP00000045136
NCBI entrez gene - 427514     See in Manteia.
RefSeq - NM_001031456
RefSeq - XM_015292123
RefSeq - XM_015292124
RefSeq Peptide - NP_001026627
swissprot - A0A1D5P1W4
swissprot - A0A1D5NXN7
swissprot - F1NSG6
Ensembl - ENSGALG00000007970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pias1aENSDARG00000036094Danio rerio
 pias1bENSDARG00000062445Danio rerio
 PIAS1ENSG00000033800Homo sapiens
 Pias1ENSMUSG00000032405Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIAS2 / protein inhibitor of activated STAT 2 / O75928* / Q8C5D8* / E3 SUMO-protein ligase PIAS2 *ENSGALG0000003943451
PIAS3* / O54714* / Q9Y6X2* / E3 SUMO-protein ligase PIAS3 * / protein inhibitor of activated STAT 3*ENSGALG0000003404235
PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*ENSGALG0000003441334
ZMIZ1 / zinc finger MIZ-type containing 1 / Q6P1E1* / Q9ULJ6*ENSGALG0000000485019


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045444 fat cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061665 SUMO ligase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction






 

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