ENSG00000033800


Homo sapiens

Features
Gene ID: ENSG00000033800
  
Biological name :PIAS1
  
Synonyms : O75925 / PIAS1 / protein inhibitor of activated STAT 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q23
Gene start: 68054179
Gene end: 68198603
  
Corresponding Affymetrix probe sets: 217862_at (Human Genome U133 Plus 2.0 Array)   217863_at (Human Genome U133 Plus 2.0 Array)   217864_s_at (Human Genome U133 Plus 2.0 Array)   242278_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438574
Ensembl peptide - ENSP00000456721
Ensembl peptide - ENSP00000457698
Ensembl peptide - ENSP00000249636
Ensembl peptide - ENSP00000456558
NCBI entrez gene - 8554     See in Manteia.
OMIM - 603566
RefSeq - XM_017022691
RefSeq - NM_016166
RefSeq - XM_011522126
RefSeq - XM_011522127
RefSeq - XM_017022688
RefSeq - XM_017022689
RefSeq - XM_017022690
RefSeq - NM_001320687
RefSeq Peptide - NP_001307616
RefSeq Peptide - NP_057250
swissprot - H3BSI8
swissprot - H3BUL7
swissprot - O75925
swissprot - H3BS65
Ensembl - ENSG00000033800
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pias1aENSDARG00000036094Danio rerio
 pias1bENSDARG00000062445Danio rerio
 PIAS1ENSGALG00000007970Gallus gallus
 Pias1ENSMUSG00000032405Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIAS3 / Q9Y6X2 / protein inhibitor of activated STAT 3ENSG0000013178857
PIAS2 / O75928 / protein inhibitor of activated STAT 2ENSG0000007804355
PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4ENSG0000010522937
ZMIZ1 / Q9ULJ6 / zinc finger MIZ-type containing 1ENSG0000010817522
ZMIZ2 / Q8NF64 / zinc finger MIZ-type containing 2ENSG0000012251521


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0016925 protein sumoylation IDA
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0033235 positive regulation of protein sumoylation IDA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0065004 protein-DNA complex assembly IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity EXP
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding NAS
 molecular_functionGO:0061665 SUMO ligase activity IDA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr