ENSG00000078043


Homo sapiens

Features
Gene ID: ENSG00000078043
  
Biological name :PIAS2
  
Synonyms : O75928 / PIAS2 / protein inhibitor of activated STAT 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q21.1
Gene start: 46803224
Gene end: 46920160
  
Corresponding Affymetrix probe sets: 1555513_at (Human Genome U133 Plus 2.0 Array)   1555514_a_at (Human Genome U133 Plus 2.0 Array)   1556492_a_at (Human Genome U133 Plus 2.0 Array)   214442_s_at (Human Genome U133 Plus 2.0 Array)   214593_at (Human Genome U133 Plus 2.0 Array)   235107_at (Human Genome U133 Plus 2.0 Array)   238700_at (Human Genome U133 Plus 2.0 Array)   243624_at (Human Genome U133 Plus 2.0 Array)   37433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466596
Ensembl peptide - ENSP00000465676
Ensembl peptide - ENSP00000468017
Ensembl peptide - ENSP00000479025
Ensembl peptide - ENSP00000468166
Ensembl peptide - ENSP00000317163
Ensembl peptide - ENSP00000381648
Ensembl peptide - ENSP00000443238
Ensembl peptide - ENSP00000465312
NCBI entrez gene - 9063     See in Manteia.
OMIM - 603567
RefSeq - XM_017026072
RefSeq - NM_001324049
RefSeq - NM_001324051
RefSeq - NM_001324052
RefSeq - NM_001324053
RefSeq - NM_001324054
RefSeq - NM_001324055
RefSeq - NM_001324057
RefSeq - NM_001324058
RefSeq - NM_001324059
RefSeq - NM_001324060
RefSeq - NM_001354033
RefSeq - NM_001354034
RefSeq - NM_001354035
RefSeq - NM_001354036
RefSeq - NM_001354038
RefSeq - NM_001354039
RefSeq - NM_004671
RefSeq - NM_173206
RefSeq - XM_005258377
RefSeq - XM_005258379
RefSeq - XM_006722571
RefSeq - XM_006722572
RefSeq - XM_006722573
RefSeq - XM_011526258
RefSeq - XM_011526259
RefSeq - XM_017026068
RefSeq - XM_017026069
RefSeq - XM_017026070
RefSeq - XM_017026071
RefSeq - NM_001324046
RefSeq - NM_001324047
RefSeq - NM_001324048
RefSeq Peptide - NP_001310976
RefSeq Peptide - NP_001340963
RefSeq Peptide - NP_001340964
RefSeq Peptide - NP_001340965
RefSeq Peptide - NP_001340967
RefSeq Peptide - NP_001340968
RefSeq Peptide - NP_004662
RefSeq Peptide - NP_775298
RefSeq Peptide - NP_001310975
RefSeq Peptide - NP_001310977
RefSeq Peptide - NP_001310978
RefSeq Peptide - NP_001310980
RefSeq Peptide - NP_001310981
RefSeq Peptide - NP_001310982
RefSeq Peptide - NP_001310983
RefSeq Peptide - NP_001310984
RefSeq Peptide - NP_001310986
RefSeq Peptide - NP_001310987
RefSeq Peptide - NP_001310988
RefSeq Peptide - NP_001310989
RefSeq Peptide - NP_001340962
swissprot - A0A0A0MS92
swissprot - K7EJT4
swissprot - K7EMP6
swissprot - K7EQX5
swissprot - K7ER97
swissprot - B4DGW0
swissprot - O75928
swissprot - A0A087WUY7
Ensembl - ENSG00000078043
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pias2ENSDARG00000092979Danio rerio
 PIAS2ENSGALG00000039434Gallus gallus
 Pias2ENSMUSG00000025423Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIAS1 / O75925 / protein inhibitor of activated STAT 1ENSG0000003380057
PIAS3 / Q9Y6X2 / protein inhibitor of activated STAT 3ENSG0000013178855
PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4ENSG0000010522939
ZMIZ2 / Q8NF64 / zinc finger MIZ-type containing 2ENSG0000012251524
ZMIZ1 / Q9ULJ6 / zinc finger MIZ-type containing 1ENSG0000010817522


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR027228  E3 SUMO-protein ligase PIAS2
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0045667 regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding NAS
 molecular_functionGO:0061665 SUMO ligase activity IDA


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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