ENSG00000131788


Homo sapiens

Features
Gene ID: ENSG00000131788
  
Biological name :PIAS3
  
Synonyms : PIAS3 / protein inhibitor of activated STAT 3 / Q9Y6X2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.1
Gene start: 145848522
Gene end: 145859836
  
Corresponding Affymetrix probe sets: 203035_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358304
Ensembl peptide - ENSP00000476245
Ensembl peptide - ENSP00000376766
Ensembl peptide - ENSP00000376765
NCBI entrez gene - 10401     See in Manteia.
OMIM - 605987
RefSeq - NM_006099
RefSeq Peptide - NP_006090
swissprot - E7ESB4
swissprot - E9PHH8
swissprot - Q9Y6X2
swissprot - U3KQV1
Ensembl - ENSG00000131788
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034042Gallus gallus
 Pias3ENSMUSG00000028101Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIAS1 / O75925 / protein inhibitor of activated STAT 1ENSG0000003380059
PIAS2 / O75928 / protein inhibitor of activated STAT 2ENSG0000007804354
PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4ENSG0000010522938
ZMIZ2 / Q8NF64 / zinc finger MIZ-type containing 2ENSG0000012251522
ZMIZ1 / Q9ULJ6 / zinc finger MIZ-type containing 1ENSG0000010817520


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR027226  E3 SUMO-protein ligase PIAS3
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0033234 negative regulation of protein sumoylation IDA
 biological_processGO:0033235 positive regulation of protein sumoylation IDA
 biological_processGO:0045838 positive regulation of membrane potential IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity EXP
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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