ENSMUSG00000028101


Mus musculus

Features
Gene ID: ENSMUSG00000028101
  
Biological name :Pias3
  
Synonyms : E3 SUMO-protein ligase PIAS3 / O54714 / Pias3
  
Possible biological names infered from orthology : protein inhibitor of activated STAT 3 / Q9Y6X2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96696384
Gene end: 96706070
  
Corresponding Affymetrix probe sets: 10494509 (MoGene1.0st)   1421646_a_at (Mouse Genome 430 2.0 Array)   1451115_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134835
Ensembl peptide - ENSMUSP00000125747
Ensembl peptide - ENSMUSP00000135843
Ensembl peptide - ENSMUSP00000069259
Ensembl peptide - ENSMUSP00000102691
Ensembl peptide - ENSMUSP00000102692
Ensembl peptide - ENSMUSP00000125377
NCBI entrez gene - 229615     See in Manteia.
MGI - MGI:1913126
RefSeq - XM_006501393
RefSeq - NM_001165949
RefSeq - NM_018812
RefSeq - NM_146135
RefSeq Peptide - NP_666247
RefSeq Peptide - NP_001159421
RefSeq Peptide - NP_061282
swissprot - H3BLM4
swissprot - E0CZH5
swissprot - H3BJ41
swissprot - O54714
swissprot - E0CZ31
Ensembl - ENSMUSG00000028101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034042Gallus gallus
 PIAS3ENSG00000131788Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pias1 / O88907 / protein inhibitor of activated STAT 1 / O75925*ENSMUSG0000003240560
Pias2 / Q8C5D8 / E3 SUMO-protein ligase PIAS2 / O75928* / protein inhibitor of activated STAT 2*ENSMUSG0000002542354
Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*ENSMUSG0000000493437
Zmiz2 / Q8CIE2 / zinc finger, MIZ-type containing 2 / Q8NF64*ENSMUSG0000004116422
Zmiz1 / Q6P1E1 / zinc finger, MIZ-type containing 1 / Q9ULJ6*ENSMUSG0000000781720


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR027226  E3 SUMO-protein ligase PIAS3
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016925 protein sumoylation IDA
 biological_processGO:0033234 negative regulation of protein sumoylation ISO
 biological_processGO:0033235 positive regulation of protein sumoylation ISO
 biological_processGO:0045838 positive regulation of membrane potential IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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