ENSMUSG00000007817


Mus musculus

Features
Gene ID: ENSMUSG00000007817
  
Biological name :Zmiz1
  
Synonyms : Q6P1E1 / zinc finger, MIZ-type containing 1 / Zmiz1
  
Possible biological names infered from orthology : Q9ULJ6
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 25459185
Gene end: 25666743
  
Corresponding Affymetrix probe sets: 10413185 (MoGene1.0st)   10413220 (MoGene1.0st)   1435740_at (Mouse Genome 430 2.0 Array)   1441823_at (Mouse Genome 430 2.0 Array)   1444505_at (Mouse Genome 430 2.0 Array)   1455984_at (Mouse Genome 430 2.0 Array)   1456816_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007961
Ensembl peptide - ENSMUSP00000124863
NCBI entrez gene - 328365     See in Manteia.
MGI - MGI:3040693
RefSeq - XM_006519134
RefSeq - NM_001310666
RefSeq - NM_183208
RefSeq Peptide - NP_899031
RefSeq Peptide - NP_001297595
swissprot - Q6P1E1
Ensembl - ENSMUSG00000007817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zmiz1aENSDARG00000074502Danio rerio
 zmiz1bENSDARG00000102279Danio rerio
 ZMIZ1ENSGALG00000004850Gallus gallus
 ZMIZ1ENSG00000108175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zmiz2 / Q8CIE2 / zinc finger, MIZ-type containing 2 / Q8NF64*ENSMUSG0000004116453
Pias2 / Q8C5D8 / E3 SUMO-protein ligase PIAS2 / O75928* / protein inhibitor of activated STAT 2*ENSMUSG0000002542313
Pias1 / O88907 / protein inhibitor of activated STAT 1 / O75925*ENSMUSG0000003240513
Pias3 / O54714 / E3 SUMO-protein ligase PIAS3 / Q9Y6X2* / protein inhibitor of activated STAT 3*ENSMUSG0000002810112
Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*ENSMUSG0000000493410


Protein motifs (from Interpro)
Interpro ID Name
 IPR004181  Zinc finger, MIZ-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007296 vitellogenesis IMP
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048844 artery morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
Show

Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0012732 abnormal perineural vascular plexus morphology "any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and is recruited to surround the neural tube in response to VEGF; vascularization of the brain and spinal cord occurs via angiogenesis as sprouting vessels from the PNVP invade the neuroepithelium and grow inward toward the ventricular lumen" [MGI:anna]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0014224 increased ileal goblet cell number 
Show

Allelic Composition: Ubl4atm1.2Arte/Ubl4atm1.2Arte
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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