ENSMUSG00000004934


Mus musculus

Features
Gene ID: ENSMUSG00000004934
  
Biological name :Pias4
  
Synonyms : Pias4 / protein inhibitor of activated STAT 4 / Q9JM05
  
Possible biological names infered from orthology : Q8N2W9
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 81153266
Gene end: 81167923
  
Corresponding Affymetrix probe sets: 10371067 (MoGene1.0st)   1418861_at (Mouse Genome 430 2.0 Array)   1440075_at (Mouse Genome 430 2.0 Array)   1455394_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005064
Ensembl peptide - ENSMUSP00000121361
NCBI entrez gene - 59004     See in Manteia.
MGI - MGI:2136940
RefSeq - NM_021501
RefSeq Peptide - NP_067476
swissprot - F6RKH8
swissprot - Q3ULQ6
swissprot - Q9JM05
Ensembl - ENSMUSG00000004934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pias4aENSDARG00000007081Danio rerio
 pias4bENSDARG00000042215Danio rerio
 PIAS4ENSGALG00000034413Gallus gallus
 PIAS4ENSG00000105229Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pias1 / O88907 / protein inhibitor of activated STAT 1 / O75925*ENSMUSG0000003240547
Pias2 / Q8C5D8 / E3 SUMO-protein ligase PIAS2 / O75928* / protein inhibitor of activated STAT 2*ENSMUSG0000002542346
Pias3 / O54714 / E3 SUMO-protein ligase PIAS3 / Q9Y6X2* / protein inhibitor of activated STAT 3*ENSMUSG0000002810145
Zmiz2 / Q8CIE2 / zinc finger, MIZ-type containing 2 / Q8NF64*ENSMUSG0000004116421
Zmiz1 / Q6P1E1 / zinc finger, MIZ-type containing 1 / Q9ULJ6*ENSMUSG0000000781721


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR027224  E3 SUMO-protein ligase PIAS4
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007259 JAK-STAT cascade ISA
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016925 protein sumoylation ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1902174 positive regulation of keratinocyte apoptotic process IDA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:1990234 transferase complex IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061665 SUMO ligase activity IDA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa6tm1Hhs/Ncoa6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa6tm1Hhs/Ncoa6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / reaction / complex
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex / reaction






 

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