ENSDARG00000042215


Danio rerio

Features
Gene ID: ENSDARG00000042215
  
Biological name :pias4b
  
Synonyms : pias4b / protein inhibitor of activated STAT, 4b
  
Possible biological names infered from orthology : PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9 / Q9JM05
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 57447105
Gene end: 57473991
  
Corresponding Affymetrix probe sets: Dr.10242.1.S1_at (Zebrafish Array)   NM_200343_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124200
Ensembl peptide - ENSDARP00000124244
Ensembl peptide - ENSDARP00000145407
NCBI entrez gene - 393314     See in Manteia.
RefSeq - NM_200343
RefSeq - NM_001242942
RefSeq Peptide - NP_001229871
RefSeq Peptide - NP_956637
swissprot - F8W4G0
swissprot - F8W4B9
ZFIN ID - ZDB-GENE-040426-1298
Ensembl - ENSDARG00000042215
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIAS4ENSGALG00000034413Gallus gallus
 PIAS4ENSG00000105229Homo sapiens
 Pias4ENSMUSG00000004934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pias4a / protein inhibitor of activated STAT, 4a / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*ENSDARG0000000708142
pias1b / protein inhibitor of activated STAT, 1b / PIAS1* / O88907* / O75925* / protein inhibitor of activated STAT 1*ENSDARG0000006244537
pias2 / protein inhibitor of activated STAT, 2 / O75928* / Q8C5D8* / E3 SUMO-protein ligase PIAS2 *ENSDARG0000009297935
pias1a / protein inhibitor of activated STAT, 1a / PIAS1* / O88907* / O75925* / protein inhibitor of activated STAT 1*ENSDARG0000003609435
zmiz1a / zinc finger, MIZ-type containing 1a / ZMIZ1* / Q6P1E1* / Q9ULJ6* / zinc finger MIZ-type containing 1*ENSDARG0000007450219
zmiz2 / zinc finger, MIZ-type containing 2 / Q8CIE2* / Q8NF64*ENSDARG0000009868319
zmiz1b / zinc finger, MIZ-type containing 1b / ZMIZ1* / Q6P1E1* / Q9ULJ6* / zinc finger MIZ-type containing 1*ENSDARG0000010227916


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004181  Zinc finger, MIZ-type
 IPR023321  PINIT domain
 IPR027224  E3 SUMO-protein ligase PIAS4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019789 SUMO transferase activity IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction / complex
 ENSDARG00000019103 kdm4ab / lysine (K)-specific demethylase 4A, genome duplicate b / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / reaction / complex
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000062650 rif1 / replication timing regulatory factor 1 / Q5UIP0* / Q6PR54* / Telomere-associated protein RIF1 *  / complex
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction / complex
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction / complex
 ENSDARG00000043339 Q1LVP6 / abraxas2a / abraxas 2a, BRISC complex subunit / Q8BPZ8* / Q6UWZ7* / ABRAXAS1* / BRCA1 A complex subunit* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000071551 xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / reaction / complex
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / complex / reaction
 ENSDARG00000045704 Q5RGE5 / dclre1c / DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) / Q96SD1* / Q8K4J0* / Protein artemis * / DNA cross-link repair 1C*  / complex / reaction
 ENSDARG00000091187 BX649250.1 / UIMC1* / Q96RL1* / ubiquitin interaction motif containing 1*  / complex / reaction
 ENSDARG00000018782 kdm4aa / lysine (K)-specific demethylase 4A, genome duplicate a / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / complex / reaction
 ENSDARG00000099675 kdm4b / lysine (K)-specific demethylase 4B / O94953* / Q91VY5* / lysine demethylase 4B* / Lysine-specific demethylase 4B *  / complex / reaction
 ENSDARG00000073841 herc2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / reaction / complex
 ENSDARG00000005606 paxip1 / PAX interacting (with transcription-activation domain) protein 1 / Q6NZQ4* / Q6ZW49* / PAX interacting protein 1*  / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000099298 xrcc5 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / reaction / complex






 

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