ENSDARG00000073841


Danio rerio

Features
Gene ID: ENSDARG00000073841
  
Biological name :herc2
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase 2 / herc2
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase HERC2 / O95714 / Q4U2R1
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 37752781
Gene end: 37847875
  
Corresponding Affymetrix probe sets: Dr.1883.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000098322
Ensembl peptide - ENSDARP00000127917
NCBI entrez gene - 558479     See in Manteia.
RefSeq - XM_021477195
RefSeq - XM_021477196
swissprot - X1WCH4
swissprot - E7EYK8
ZFIN ID - ZDB-GENE-070718-6
Ensembl - ENSDARG00000073841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HERC2ENSGALG00000016739Gallus gallus
 HERC2ENSG00000128731Homo sapiens
 Herc2ENSMUSG00000030451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSDARG0000007790124
herc4 / HECT and RLD domain containing E3 ubiquitin protein ligase 4 / Q5GLZ8*ENSDARG000000599365
si:ch211-281g13.4ENSDARG000000753894
herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*ENSDARG000000758874
slc47a2.2 / solute carrier family 47 (multidrug and toxin extrusion), member 2.2ENSDARG000000741364
si:ch211-281g13.5ENSDARG000000740524
hectd3 / HECT domain containing 3 / Q3U487* / Q5T447* / E3 ubiquitin-protein ligase HECTD3 * / HECT domain E3 ubiquitin protein ligase 3*ENSDARG000000389053
HERC5 / si:ch73-190m4.1 / HERC6* / F2Z461* / Q9UII4* / Q8IVU3* / AC098582.1* / E3 ISG15--protein ligase Herc6 * / HECT and RLD domain containing E3 ubiquitin protein ligase 5* / HECT and RL...ENSDARG000000757853
herc7 / hect domain and RLD 7ENSDARG000000989062
hectd2 / HECT domain containing 2 / Q5U5R9* / Q8CDU6* / HECT domain E3 ubiquitin protein ligase 2* / Probable E3 ubiquitin-protein ligase HECTD2 *ENSDARG000000611942
rccd1 / RCC1 domain containing 1ENSDARG000000710742
ube3a / ubiquitin protein ligase E3A / O08759* / Q05086*ENSDARG000000557372


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000433  Zinc finger, ZZ-type
 IPR000569  HECT domain
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR004939  APC10/DOC domain
 IPR006624  Beta-propeller repeat TECPR
 IPR008979  Galactose-binding-like domain superfamily
 IPR009060  UBA-like superfamily
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR010606  Mib-herc2
 IPR014722  Ribosomal protein L2, domain 2
 IPR021097  CPH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction / complex
 ENSDARG00000019103 kdm4ab / lysine (K)-specific demethylase 4A, genome duplicate b / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / reaction / complex
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000062650 rif1 / replication timing regulatory factor 1 / Q5UIP0* / Q6PR54* / Telomere-associated protein RIF1 *  / complex
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction / complex
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000043339 Q1LVP6 / abraxas2a / abraxas 2a, BRISC complex subunit / Q8BPZ8* / Q6UWZ7* / ABRAXAS1* / BRCA1 A complex subunit* / abraxas 1, BRCA1 A complex subunit*  / complex / reaction
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000005606 paxip1 / PAX interacting (with transcription-activation domain) protein 1 / Q6NZQ4* / Q6ZW49* / PAX interacting protein 1*  / complex
 ENSDARG00000045704 Q5RGE5 / dclre1c / DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) / Q96SD1* / Q8K4J0* / Protein artemis * / DNA cross-link repair 1C*  / reaction / complex
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / complex / reaction
 ENSDARG00000018782 kdm4aa / lysine (K)-specific demethylase 4A, genome duplicate a / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / complex / reaction
 ENSDARG00000099675 kdm4b / lysine (K)-specific demethylase 4B / O94953* / Q91VY5* / lysine demethylase 4B* / Lysine-specific demethylase 4B *  / complex / reaction
 ENSDARG00000091187 BX649250.1 / UIMC1* / Q96RL1* / ubiquitin interaction motif containing 1*  / reaction / complex
 ENSDARG00000071551 xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSDARG00000042215 pias4b / protein inhibitor of activated STAT, 4b / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*  / reaction / complex
 ENSDARG00000099298 xrcc5 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / reaction / complex






 

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