ENSMUSG00000043909


Mus musculus

Features
Gene ID: ENSMUSG00000043909
  
Biological name :Trp53bp1
  
Synonyms : P70399 / TP53-binding protein 1 / Trp53bp1
  
Possible biological names infered from orthology : Q12888 / TP53BP1 / tumor protein p53 binding protein 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 121193281
Gene end: 121271407
  
Corresponding Affymetrix probe sets: 10486722 (MoGene1.0st)   1426956_a_at (Mouse Genome 430 2.0 Array)   1426957_at (Mouse Genome 430 2.0 Array)   1435609_at (Mouse Genome 430 2.0 Array)   1442316_x_at (Mouse Genome 430 2.0 Array)   1446100_at (Mouse Genome 430 2.0 Array)   1457812_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122629
Ensembl peptide - ENSMUSP00000119793
Ensembl peptide - ENSMUSP00000120451
Ensembl peptide - ENSMUSP00000106277
Ensembl peptide - ENSMUSP00000106278
Ensembl peptide - ENSMUSP00000114457
Ensembl peptide - ENSMUSP00000117548
Ensembl peptide - ENSMUSP00000119425
NCBI entrez gene - 27223     See in Manteia.
MGI - MGI:1351320
RefSeq - XM_017318938
RefSeq - XM_006499667
RefSeq - XM_006499668
RefSeq - XM_011239581
RefSeq - XM_011239582
RefSeq - XM_011239583
RefSeq - XM_011239584
RefSeq - XM_011239585
RefSeq - XM_017318936
RefSeq - XM_017318937
RefSeq - NM_001290830
RefSeq - NM_013735
RefSeq - XM_006499661
RefSeq - XM_006499662
RefSeq - XM_006499666
RefSeq Peptide - NP_001277759
RefSeq Peptide - NP_038763
swissprot - F6ZRL3
swissprot - F7CE65
swissprot - F6S5E4
swissprot - P70399
swissprot - A2AU90
swissprot - F6QNC8
swissprot - F6VCK5
Ensembl - ENSMUSG00000043909
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp53bp1ENSDARG00000079000Danio rerio
 TP53BP1ENSGALG00000042201Gallus gallus
 Q12888ENSG00000067369Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR014722  Ribosomal protein L2, domain 2
 IPR015125  Tumour suppressor p53-binding protein-1 Tudor domain
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IBA
 biological_processGO:0006281 DNA repair IDA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0045830 positive regulation of isotype switching IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:1990391 DNA repair complex IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0061649 ubiquitin modification-dependent histone binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79am2Btlr/Cd79am2Btlr
Genetic Background: C57BL/6J-Cd79am2Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79am2Btlr/Cd79am2Btlr
Genetic Background: C57BL/6J-Cd79am2Btlr

Allelic Composition: Trp53bp1m3Btlr/Trp53bp1m3Btlr
Genetic Background: C57BL/6J-Trp53bp1m3Btlr

Allelic Composition: Trp53bp1m4Btlr/Trp53bp1m4Btlr
Genetic Background: C57BL/6J-Trp53bp1m4Btlr

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129

Allelic Composition: Rif1Gt(XT0278)Wtsi/Rif1Gt(XT0278)Wtsi,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129P2/OlaHsd * CD-1 * MF1

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Ightm3Mnz/Ightm4.1Mnz,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79am2Btlr/Cd79am2Btlr
Genetic Background: C57BL/6J-Cd79am2Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Exo1tm1Wed/Exo1tm1Wed,Ightm4.1Mnz/Igh+
Genetic Background: involves: C57BL/6 * CBA/JNCrlj * SJL

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008409 increased cellular sensitivity to hydroxyurea "greater incidence of cell death following exposure to hydroxyurea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129

 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination "any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam17tm1.2Rain/Adam17tm1.2Rain
Genetic Background: C57BL/6-Adam17tm1.2Rain

Allelic Composition: Aicdatm1Hon/Aicdatm1Hon,Exo1tm1Wed/Exo1tm1Wed,Ightm4.1Mnz/Igh+,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129 * C57BL/6 * CBA/JNCrlj * SJL

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
Show

Allelic Composition: Cd79am2Btlr/Cd79am2Btlr
Genetic Background: C57BL/6J-Cd79am2Btlr

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129

Allelic Composition: Helbtm1(KOMP)Vlcg/Helbtm1(KOMP)Vlcg,Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic Background: involves: 129 * C57BL/6NTac

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
Show

Allelic Composition: Cd79am2Btlr/Cd79am2Btlr
Genetic Background: C57BL/6J-Cd79am2Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Cd79am2Btlr/Cd79am2Btlr
Genetic Background: C57BL/6J-Cd79am2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / complex / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / reaction / complex
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / complex / reaction
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction / complex
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction / complex
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex






 

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