ENSMUSG00000024926


Mus musculus

Features
Gene ID: ENSMUSG00000024926
  
Biological name :Kat5
  
Synonyms : Histone acetyltransferase KAT5 / Kat5 / Q8CHK4
  
Possible biological names infered from orthology : lysine acetyltransferase 5 / Q92993
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5603017
Gene end: 5610094
  
Corresponding Affymetrix probe sets: 10465114 (MoGene1.0st)   1433980_at (Mouse Genome 430 2.0 Array)   1433981_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109271
NCBI entrez gene - 81601     See in Manteia.
MGI - MGI:1932051
RefSeq - NM_001199249
RefSeq - NM_178637
RefSeq - XM_006531860
RefSeq - NM_001199247
RefSeq - NM_001199248
RefSeq - XM_006531859
RefSeq Peptide - NP_001186178
RefSeq Peptide - NP_848752
RefSeq Peptide - NP_001186176
RefSeq Peptide - NP_001186177
swissprot - Q3UJQ1
swissprot - Q8CHK4
Ensembl - ENSMUSG00000024926
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat5aENSDARG00000004587Danio rerio
 kat5bENSDARG00000045951Danio rerio
 KAT5ENSG00000172977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kat6a / lysine acetyltransferase 6A / Q92794*ENSMUSG0000003154034
Kat8 / Q9D1P2 / Histone acetyltransferase KAT8 / Q9H7Z6* / lysine acetyltransferase 8*ENSMUSG0000003080134
Kat7 / Q5SVQ0 / K(lysine) acetyltransferase 7 / O95251* / lysine acetyltransferase 7*ENSMUSG0000003890933
Kat6b / Q8BRB7 / Histone acetyltransferase KAT6B / Q8WYB5* / lysine acetyltransferase 6B*ENSMUSG0000002176732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR002717  Histone acetyltransferase domain, MYST-type
 IPR016181  Acyl-CoA N-acyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR025995  RNA binding activity-knot of a chromodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISS
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016573 histone acetylation ISO
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:1901985 positive regulation of protein acetylation IEA
 cellular_componentGO:0000812 Swr1 complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032777 Piccolo NuA4 histone acetyltransferase complex ISO
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

Allelic Composition: Kat5tm1Jwl/Kat5+,Tg(IghMyc)22Bri/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129 * C57BL * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

Allelic Composition: Kat5tm1Jwl/Kat5+,Tg(IghMyc)22Bri/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129 * C57BL * C57BL/6 * SJL

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: St6gal1tm1Jlau/St6gal1tm1Jlau
Genetic Background: B6.129S4-St6gal1tm1Jlau

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000028886 Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / complex / reaction
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / complex / reaction
 ENSMUSG00000030079 P60122 / Ruvbl1 / RuvB-like protein 1 / Q9Y265* / RuvB like AAA ATPase 1*  / complex / reaction
 ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction / complex
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex / reaction
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / complex / reaction
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / complex / reaction
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction / complex
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / complex / reaction
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / complex / reaction
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / complex / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / complex / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction / complex
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / complex / reaction






 

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