ENSMUSG00000030801


Mus musculus

Features
Gene ID: ENSMUSG00000030801
  
Biological name :Kat8
  
Synonyms : Histone acetyltransferase KAT8 / Kat8 / Q9D1P2
  
Possible biological names infered from orthology : lysine acetyltransferase 8 / Q9H7Z6
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 127912516
Gene end: 127925837
  
Corresponding Affymetrix probe sets: 10557831 (MoGene1.0st)   1432080_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033070
Ensembl peptide - ENSMUSP00000145731
NCBI entrez gene - 67773     See in Manteia.
MGI - MGI:1915023
RefSeq - XM_011241882
RefSeq - NM_026370
RefSeq - XM_006508138
RefSeq Peptide - NP_080646
swissprot - Q9D1P2
swissprot - A0A0U1RNW7
Ensembl - ENSMUSG00000030801
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat8ENSDARG00000027187Danio rerio
 KAT8ENSG00000103510Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kat7 / Q5SVQ0 / K(lysine) acetyltransferase 7 / O95251* / lysine acetyltransferase 7*ENSMUSG0000003890942
Kat6a / lysine acetyltransferase 6A / Q92794*ENSMUSG0000003154040
Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*ENSMUSG0000002492638
Kat6b / Q8BRB7 / Histone acetyltransferase KAT6B / Q8WYB5* / lysine acetyltransferase 6B*ENSMUSG0000002176737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR002717  Histone acetyltransferase domain, MYST-type
 IPR016181  Acyl-CoA N-acyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR025995  RNA binding activity-knot of a chromodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0030099 myeloid cell differentiation IEA
 biological_processGO:0043981 histone H4-K5 acetylation IEA
 biological_processGO:0043982 histone H4-K8 acetylation IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 cellular_componentGO:0072487 MSL complex IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IEA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad1tm2Rob/Smad1tm2Rob,Smad5tm1Huy/Smad5tm1Zuk,Smad9tm1Jfm/Smad9tm1Jfm
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atmtm1Led/Atmtm1Led,Kat8tm2Thl/Kat8+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Atmtm1Led/Atmtm1Led,Kat8tm2Thl/Kat8+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Kat8tm1Thl/Kat8+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Kat8tm1.1Avo/Kat8tm1.1Avo
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Kat8tm1.1Avo/Kat8tm1.1Avo
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0012117 decreased trophectoderm cell proliferation 
Show

Allelic Composition: Kat8tm1.1Avo/Kat8tm1.1Avo
Genetic Background: involves: BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047669 Msl3l2 / MSL3* / Q8N5Y2* / MSL complex subunit 3*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000052915 Msl1 / Q6PDM1 / Male-specific lethal 1 homolog / Q68DK7*  / complex
 ENSMUSG00000066415 Msl2 / Q69ZF8 / E3 ubiquitin-protein ligase MSL2 / Q9HCI7* / MSL complex subunit 2*  / complex






 

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