ENSMUSG00000021767


Mus musculus

Features
Gene ID: ENSMUSG00000021767
  
Biological name :Kat6b
  
Synonyms : Histone acetyltransferase KAT6B / Kat6b / Q8BRB7
  
Possible biological names infered from orthology : lysine acetyltransferase 6B / Q8WYB5
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 21481434
Gene end: 21672478
  
Corresponding Affymetrix probe sets: 10413100 (MoGene1.0st)   1423508_at (Mouse Genome 430 2.0 Array)   1446189_at (Mouse Genome 430 2.0 Array)   1447758_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066693
Ensembl peptide - ENSMUSP00000108077
Ensembl peptide - ENSMUSP00000138511
Ensembl peptide - ENSMUSP00000138746
Ensembl peptide - ENSMUSP00000138377
Ensembl peptide - ENSMUSP00000138421
NCBI entrez gene - 54169     See in Manteia.
MGI - MGI:1858746
RefSeq - XM_017316084
RefSeq - NM_001205241
RefSeq - NM_017479
RefSeq - XM_006519265
RefSeq - XM_006519268
RefSeq - XM_006519269
RefSeq - XM_017316082
RefSeq - XM_017316083
RefSeq - XM_006519263
RefSeq - XM_006519264
RefSeq Peptide - NP_059507
RefSeq Peptide - NP_001192170
swissprot - Q14AW2
swissprot - Q8BRB7
swissprot - S4R2Q8
Ensembl - ENSMUSG00000021767
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat6bENSDARG00000055429Danio rerio
 KAT6BENSGALG00000005035Gallus gallus
 KAT6BENSG00000156650Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kat6a / lysine acetyltransferase 6A / Q92794*ENSMUSG0000003154057
Kat7 / Q5SVQ0 / K(lysine) acetyltransferase 7 / O95251* / lysine acetyltransferase 7*ENSMUSG0000003890912
Kat8 / Q9D1P2 / Histone acetyltransferase KAT8 / Q9H7Z6* / lysine acetyltransferase 8*ENSMUSG0000003080110
Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*ENSMUSG000000249269


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002717  Histone acetyltransferase domain, MYST-type
 IPR005818  Linker histone H1/H5, domain H15
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016181  Acyl-CoA N-acyltransferase
 IPR019787  Zinc finger, PHD-finger
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016573 histone acetylation ISS
 biological_processGO:0043966 histone H3 acetylation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0070776 MOZ/MORF histone acetyltransferase complex ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IDA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0016407 acetyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000023 abnormal ear distance/ position "anomaly in the space between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Kat6bGt(pKC199)1Pgr/Kat6b+
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008969 abnormal nasolacrimal duct morphology "any structural anomaly of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009038 decreased inferior colliculus size "decreased size of the paired inferior eminence of the mesencephalic tectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010743 delayed suture closure "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0011504 abnormal limb long bone morphology 
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026283 Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*  / complex
 ENSMUSG00000028863 Meaf6 / Q2VPQ9 / MYST/Esa1-associated factor 6 / Q9HAF1*  / complex
 ENSMUSG00000001632 Brpf1 / B2RRD7 / Peregrin / P55201* / bromodomain and PHD finger containing 1*  / complex






 

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