MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+ Genetic Background: Not Specified
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MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+ Genetic Background: Not Specified
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MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0000808 | abnormal hippocampus development | "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+ Genetic Background: Not Specified
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0001447 | abnormal nest building behavior | "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
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MP:0002761 | abnormal hippocampal mossy fiber morphology | "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0003648 | abnormal radial glial cell morphology | "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0004045 | abnormal cell cycle checkpoint function | "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0004981 | decreased neuronal precursor cell number | "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+ Genetic Background: Not Specified
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MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Commd10Tg(Vav1-icre)A2Kio/Commd10+ Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Allelic Composition: Brpf1tm1d(EUCOMM)Wtsi/Brpf1tm1d(EUCOMM)Wtsi Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
Allelic Composition: Brpf1tm1d(EUCOMM)Wtsi/Brpf1+ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6N
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MP:0006009 | abnormal neuronal migration | "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0008262 | abnormal hippocampus region morphology | "any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0008263 | abnormal hippocampus CA1 region morphology | |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0008284 | abnormal hippocampus pyramidal cell layer | |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0008441 | thin cortical plate | "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0008547 | abnormal neocortex morphology | "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0009939 | abnormal hippocampus neuron morphology | |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0010865 | prenatal growth retardation | "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
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MP:0011940 | decreased food intake | "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0012203 | abnormal neuronal stem cell morphology | "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0012460 | decreased dentate gyrus size | "reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0014134 | abnormal embryo morphology | "any structural anomaly of an embryo " [MGI:csmith] |
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
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MP:0020069 | decreased neocortex size | "size reduction or truncation of the neocortex" [GOC:NV] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0020388 | decreased radial glial cell number | "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0020394 | decreased neuronal precursor proliferation | "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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MP:0020536 | increased subiculum size | "increase in the size of the subiculum" [MGI:smb] |
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Allelic Composition: Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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