ENSMUSG00000022387


Mus musculus

Features
Gene ID: ENSMUSG00000022387
  
Biological name :Brd1
  
Synonyms : Brd1 / bromodomain containing 1
  
Possible biological names infered from orthology : O95696
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 88687034
Gene end: 88734233
  
Corresponding Affymetrix probe sets: 10431284 (MoGene1.0st)   1434821_at (Mouse Genome 430 2.0 Array)   1438771_at (Mouse Genome 430 2.0 Array)   1447420_at (Mouse Genome 430 2.0 Array)   1456692_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105007
Ensembl peptide - ENSMUSP00000105006
NCBI entrez gene - 223770     See in Manteia.
MGI - MGI:1924161
RefSeq - XM_006520834
RefSeq - XM_006520836
RefSeq - NM_001033274
RefSeq - XM_006520835
RefSeq Peptide - NP_001028446
swissprot - G5E8P1
swissprot - E9PZ26
Ensembl - ENSMUSG00000022387
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brd1aENSDARG00000013596Danio rerio
 brd1bENSDARG00000051798Danio rerio
 BRD1ENSGALG00000029379Gallus gallus
 BRD1ENSG00000100425Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brpf3 / bromodomain and PHD finger containing, 3 / Q9ULD4*ENSMUSG0000006395253
Brpf1 / B2RRD7 / Peregrin / P55201* / bromodomain and PHD finger containing 1*ENSMUSG0000000163252
Jade3 / Q6IE82 / Protein Jade-3 / Q92613* / jade family PHD finger 3*ENSMUSG0000003731516
Jade1 / Q6ZPI0 / Protein Jade-1 / Q6IE81* / jade family PHD finger 1*ENSMUSG0000002576415
Mllt10 / O54826 / myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 / P55197* / MLLT10, histone lysine methyltransferase DOT1L cofactor*ENSMUSG0000002674314
Phf14 / Q9D4H9 / PHD finger protein 14 / O94880*ENSMUSG0000002962914
Mllt6 / MLLT6, PHD finger containingENSMUSG0000003843714
Jade2 / Q6ZQF7 / Mus musculus jade family PHD finger 2 (Jade2), transcript variant 1, mRNA. / Q9NQC1* / jade family PHD finger 2*ENSMUSG0000002038714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001487  Bromodomain
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018359  Bromodomain, conserved site
 IPR019542  Enhancer of polycomb-like, N-terminal
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR034732  Extended PHD (ePHD) domain
 IPR035502  BR140-related, PWWD domain
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0043966 histone H3 acetylation ISO
 biological_processGO:0051602 response to electrical stimulus IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0070776 MOZ/MORF histone acetyltransferase complex ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
Regulation of TP53 Activity through Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0011246 abnormal fetal liver hematopoietic progenitor cell morphology "any structural anomaly of a hematopoietic stem cell that resides in the fetal liver; in mice, this cell type is first observed at E10.5" [CL:0002353]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

 MP:0012243 decreased hepatoblast number "reduced number of the bi-potent cells that retain the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [MGI:anna]
Show

Allelic Composition: Ddctm1.1Rhrs/Ddctm1.1Rhrs,Tg(Ggt1-cre)M3Egn/0
Genetic Background: 129.Cg-Ddctm1.1Rhrs Tg(Ggt1-cre)M3Egn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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