ENSMUSG00000036986


Mus musculus

Features
Gene ID: ENSMUSG00000036986
  
Biological name :Pml
  
Synonyms : Pml / Protein PML / Q60953
  
Possible biological names infered from orthology : P29590 / promyelocytic leukemia
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 58218076
Gene end: 58249786
  
Corresponding Affymetrix probe sets: 10594053 (MoGene1.0st)   1448757_at (Mouse Genome 430 2.0 Array)   1456103_at (Mouse Genome 430 2.0 Array)   1459137_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118955
Ensembl peptide - ENSMUSP00000118232
Ensembl peptide - ENSMUSP00000120620
Ensembl peptide - ENSMUSP00000122854
Ensembl peptide - ENSMUSP00000121380
Ensembl peptide - ENSMUSP00000121330
Ensembl peptide - ENSMUSP00000082816
Ensembl peptide - ENSMUSP00000109771
Ensembl peptide - ENSMUSP00000116787
NCBI entrez gene - 18854     See in Manteia.
MGI - MGI:104662
RefSeq - XM_017313212
RefSeq - NM_001311088
RefSeq - NM_008884
RefSeq - NM_178087
RefSeq - XM_006510860
RefSeq - XM_006510861
RefSeq - XM_006510862
RefSeq - XM_006510864
RefSeq Peptide - NP_001298017
RefSeq Peptide - NP_032910
RefSeq Peptide - NP_835188
swissprot - D6RII9
swissprot - D3Z3A6
swissprot - D3Z2V0
swissprot - F6RQM1
swissprot - F6XUT1
swissprot - F7BTZ2
swissprot - D3YXR5
swissprot - Q60953
swissprot - A0A068EW80
Ensembl - ENSMUSG00000036986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045534Gallus gallus
 ENSGALG00000045105Gallus gallus
 PMLENSG00000140464Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR021978  Protein of unknown function DUF3583


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006605 protein targeting ISS
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007182 common-partner SMAD protein phosphorylation IMP
 biological_processGO:0007569 cell aging IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ISO
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0010522 regulation of calcium ion transport into cytosol IMP
 biological_processGO:0010761 fibroblast migration IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0030578 PML body organization ISO
 biological_processGO:0031065 positive regulation of histone deacetylation ISS
 biological_processGO:0032206 positive regulation of telomere maintenance ISO
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase ISO
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IMP
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0032938 negative regulation of translation in response to oxidative stress ISO
 biological_processGO:0034097 response to cytokine ISO
 biological_processGO:0042752 regulation of circadian rhythm IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045343 regulation of MHC class I biosynthetic process IDA
 biological_processGO:0045345 positive regulation of MHC class I biosynthetic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050711 negative regulation of interleukin-1 secretion IMP
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051457 maintenance of protein location in nucleus ISO
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051974 negative regulation of telomerase activity ISO
 biological_processGO:0060058 positive regulation of apoptotic process involved in mammary gland involution ISO
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0065003 protein-containing complex assembly ISS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:0090398 cellular senescence ISS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:1902187 negative regulation of viral release from host cell IDA
 biological_processGO:1904816 positive regulation of protein localization to chromosome, telomeric region ISO
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process ISO
 biological_processGO:2000779 regulation of double-strand break repair ISO
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISO
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0042406 extrinsic component of endoplasmic reticulum membrane IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0032183 SUMO binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046332 SMAD binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0050897 cobalt ion binding ISO


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Regulation of TP53 Activity through Acetylation
Regulation of RUNX1 Expression and Activity
Regulation of PTEN localization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pmltm1(PML/RARA)Ley/Pml+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Pmltm1(PML/RARA)Ley/Pml+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: Not Specified

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmltm1(PML/RARA)Ley/Pml+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmltm1(PML/RARA)Ley/Pml+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: Not Specified

Allelic Composition: Pmltm1(PML/RARA)Ley/Pml+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028863 Meaf6 / Q2VPQ9 / MYST/Esa1-associated factor 6 / Q9HAF1*  / complex / reaction
 ENSMUSG00000026283 Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000001632 Brpf1 / B2RRD7 / Peregrin / P55201* / bromodomain and PHD finger containing 1*  / reaction / complex
 ENSMUSG00000031540 Kat6a / lysine acetyltransferase 6A / Q92794*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex






 

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