ENSMUSG00000001729


Mus musculus

Features
Gene ID: ENSMUSG00000001729
  
Biological name :Akt1
  
Synonyms : Akt1 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31750
  
Possible biological names infered from orthology : AKT serine/threonine kinase 1 / P31749
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 112653821
Gene end: 112674884
  
Corresponding Affymetrix probe sets: 10402766 (MoGene1.0st)   1416657_at (Mouse Genome 430 2.0 Array)   1425711_a_at (Mouse Genome 430 2.0 Array)   1440950_at (Mouse Genome 430 2.0 Array)   1442759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122222
Ensembl peptide - ENSMUSP00000123689
Ensembl peptide - ENSMUSP00000001780
Ensembl peptide - ENSMUSP00000118190
NCBI entrez gene - 11651     See in Manteia.
MGI - MGI:87986
RefSeq - XM_006515416
RefSeq - NM_001165894
RefSeq - NM_001331107
RefSeq - NM_009652
RefSeq - XM_006515415
RefSeq Peptide - NP_001318036
RefSeq Peptide - NP_033782
RefSeq Peptide - NP_001159366
swissprot - P31750
swissprot - D3Z783
swissprot - D3YXX3
swissprot - D3YYP9
Ensembl - ENSMUSG00000001729
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt1ENSDARG00000099657Danio rerio
 AKT1ENSGALG00000011620Gallus gallus
 AKT1ENSG00000142208Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969982
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405682
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110839
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503839
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288938
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096538
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881637
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997037
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194837
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677836
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905335
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764335
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591535
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786833


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR034676  Protein kinase B alpha, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005978 glycogen biosynthetic process IEA
 biological_processGO:0005979 regulation of glycogen biosynthetic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006924 activation-induced cell death of T cells IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress ISS
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IDA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IMP
 biological_processGO:0010765 positive regulation of sodium ion transport IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010975 regulation of neuron projection development IDA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030163 protein catabolic process IDA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031641 regulation of myelination IMP
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032094 response to food IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032287 peripheral nervous system myelin maintenance IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0036294 cellular response to decreased oxygen levels IDA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043491 protein kinase B signaling IGI
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045792 negative regulation of cell size IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0046622 positive regulation of organ growth IMP
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051146 striated muscle cell differentiation IGI
 biological_processGO:0060416 response to growth hormone ISS
 biological_processGO:0060709 glycogen cell differentiation involved in embryonic placenta development IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0070141 response to UV-A IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0072656 maintenance of protein location in mitochondrion IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
 biological_processGO:0097194 execution phase of apoptosis IDA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901653 cellular response to peptide IDA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990418 response to insulin-like growth factor stimulus ISS
 biological_processGO:2000010 positive regulation of protein localization to cell surface IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
mTOR signalling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity
Negative regulation of NOTCH4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001238 thin epidermal spinous layer "reduced thickness of the stratum spinosum; the polyhedral cell layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:15108]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1+,Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gjc2tm1Paul/Gjc2tm1Paul,Gjb1tm1Kwi/Gjb1tm1Kwi
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Hem/Akt1+,Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Akt3tm1Nhy/Akt3tm1Nhy
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/1LacJ

 MP:0001711 abnormal placenta 
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/1LacJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6

Allelic Composition: Akt1Gt1Pnt/Akt1Gt1Pnt,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Tg(Lck-cre)1Cwi/0
Genetic Background: Not Specified

Allelic Composition: Akt1tm2.2Mbb/Akt1tm2.2Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0004126 thin hypodermis "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: B6.129P2-Akt1tm1Mbb

Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Akt1tm1Mbb/Akt1tm1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012109 decreased trophoblast glycogen cell number "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
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Allelic Composition: Akt1tm2.1Mbb/Akt1tm2.1Mbb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000044167 Foxo1 / Q9R1E0 / Forkhead box protein O1 / Q12778* / forkhead box O1*  / reaction
 ENSMUSG00000024830 Q9Z1M4 / Rps6kb2 / ribosomal protein S6 kinase, polypeptide 2 / Q9UBS0* / ribosomal protein S6 kinase B2*  / reaction
 ENSMUSG00000028145 Them4 / Q3UUI3 / Acyl-coenzyme A thioesterase THEM4 / Q5T1C6* / thioesterase superfamily member 4*  / reaction / complex
 ENSMUSG00000048756 Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*  / reaction
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000031540 Kat6a / lysine acetyltransferase 6A / Q92794*  / reaction
 ENSMUSG00000001632 Brpf1 / B2RRD7 / Peregrin / P55201* / bromodomain and PHD finger containing 1*  / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction
 ENSMUSG00000026283 Ing5 / Q9D8Y8 / Inhibitor of growth protein 5 / Q8WYH8* / inhibitor of growth family member 5*  / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / reaction
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / reaction
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction
 ENSMUSG00000021127 P23950 / Zfp36l1 / zinc finger protein 36, C3H type-like 1 / Q07352* / ZFP36 ring finger protein like 1*  / reaction
 ENSMUSG00000028863 Meaf6 / Q2VPQ9 / MYST/Esa1-associated factor 6 / Q9HAF1*  / reaction
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / reaction
 ENSMUSG00000007670 Khsrp / Q3U0V1 / KH-type splicing regulatory protein / Q92945*  / reaction
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / reaction
 ENSMUSG00000029922 Mkrn1 / Q9QXP6 / makorin, ring finger protein, 1 / Q9UHC7*  / reaction
 ENSMUSG00000023034 Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*  / reaction
 ENSMUSG00000038116 Phf20 / Q8BLG0 / PHD finger protein 20 / Q9BVI0*  / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction
 ENSMUSG00000035392 Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*  / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction
 ENSMUSG00000032715 Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*  / reaction / complex
 ENSMUSG00000002496 Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*  / reaction
 ENSMUSG00000042903 Foxo4 / Q9WVH3 / Forkhead box protein O4 / P98177* / forkhead box O4*  / reaction
 ENSMUSG00000022428 1 / Cby1 / Q9D1C2 / Q9Y3M2* / chibby family member 1, beta catenin antagonist*  / reaction
 ENSMUSG00000028914 Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*  / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction
 ENSMUSG00000015468 Notch4 / Q99466*  / reaction
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000024777 Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*  / reaction
 ENSMUSG00000031732 Phlpp2 / Q8BXA7 / PH domain leucine-rich repeat-containing protein phosphatase 2 / Q6ZVD8* / PH domain and leucine rich repeat protein phosphatase 2*  / reaction
 ENSMUSG00000028978 Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*  / complex / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / complex / reaction
 ENSMUSG00000044340 Phlpp1 / Q8CHE4 / PH domain leucine-rich repeat-containing protein phosphatase 1 / O60346* / PH domain and leucine rich repeat protein phosphatase 1*  / reaction
 ENSMUSG00000017843 Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*  / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr