ENSMUSG00000019699


Mus musculus

Features
Gene ID: ENSMUSG00000019699
  
Biological name :Akt3
  
Synonyms : Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase
  
Possible biological names infered from orthology : AKT serine/threonine kinase 3 / Q9Y243
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H4
Gene start: 177020073
Gene end: 177258203
  
Corresponding Affymetrix probe sets: 10360506 (MoGene1.0st)   1422078_at (Mouse Genome 430 2.0 Array)   1435260_at (Mouse Genome 430 2.0 Array)   1435879_at (Mouse Genome 430 2.0 Array)   1460307_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019843
Ensembl peptide - ENSMUSP00000106789
Ensembl peptide - ENSMUSP00000106790
NCBI entrez gene - 23797     See in Manteia.
MGI - MGI:1345147
RefSeq - XM_017320418
RefSeq - NM_011785
RefSeq - XM_006496819
RefSeq - XM_011238805
RefSeq - XM_006496818
RefSeq Peptide - NP_035915
swissprot - Q9WUA6
Ensembl - ENSMUSG00000019699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt3aENSDARG00000104810Danio rerio
 AKT3ENSGALG00000034081Gallus gallus
 AKT3ENSG00000117020Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172982
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405677
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503838
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194838
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288937
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881637
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110837
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997037
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096537
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677836
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591535
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764335
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786834
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR034675  Protein kinase B gamma, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance ISO
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0010765 positive regulation of sodium ion transport ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045793 positive regulation of cell size IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1905653 positive regulation of artery morphogenesis IMP
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Tbx15tm1Akis/Tbx15tm1Akis
Genetic Background: involves: 129P2/OlaHsd * NMRI

Allelic Composition: Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1+,Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Hem/Akt1+,Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Akt3tm1Nhy/Akt3tm1Nhy
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/1LacJ

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6

Allelic Composition: Akt3tm1Mbb/Akt3tm1Mbb,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch1tm1Grid/Notch1tm1Grid,Notch4tm1Grid/Notch4tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0002194 maximal tonic hindlimb extension seizures "seizures induced by electrical stimulation of the brainstem; manifesting as a tonic-clonic flexion/extension sequence, starting in tonic extension of the forelimbs and terminating in a full tonic hindlimb extension, which is defined when the angle of the hindlimbs to the torso exceeds 90 degrees (although it is usually 180 degrees)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Akt3tm1Nhy/Akt3tm1Nhy
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/1LacJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt1tm1Pnt/Akt1tm1Pnt,Akt2tm1.1Mbb/Akt2tm1.1Mbb,Akt3tm1Mbb/Akt3tm1Mbb,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008282 enlarged hippocampus "increased size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt3Nmf350/Akt3Nmf350
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Akt2tm1Hem/Akt2tm1Hem,Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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