ENSGALG00000034081


Gallus gallus

Features
Gene ID: ENSGALG00000034081
  
Biological name :AKT3
  
Synonyms : AKT3 / AKT serine/threonine kinase 3
  
Possible biological names infered from orthology : Q9WUA6 / Q9Y243 / RAC-gamma serine/threonine-protein kinase
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 35081760
Gene end: 35226507
  
Corresponding Affymetrix probe sets: Gga.12898.1.S1_at (Chicken Array)   GgaAffx.20776.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043796
Ensembl peptide - ENSGALP00000062481
NCBI entrez gene - 421497     See in Manteia.
RefSeq - XM_015283981
RefSeq - XM_015283982
RefSeq - XM_015283983
RefSeq - XM_015283984
swissprot - A0A1L1RUI3
swissprot - A0A1D5NTY9
Ensembl - ENSGALG00000034081
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt3aENSDARG00000104810Danio rerio
 AKT3ENSG00000117020Homo sapiens
 Akt3ENSMUSG00000019699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162085
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595038
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188938
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201638
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000037
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794337
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357036
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497036
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397135
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936435
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127034
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353734


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 biological_processGO:1905653 positive regulation of artery morphogenesis IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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