ENSGALG00000010000


Gallus gallus

Features
Gene ID: ENSGALG00000010000
  
Biological name :PRKCE
  
Synonyms : PRKCE / protein kinase C epsilon
  
Possible biological names infered from orthology : P16054 / Q02156
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 26395277
Gene end: 26573746
  
Corresponding Affymetrix probe sets: GgaAffx.6286.1.S1_s_at (Chicken Array)   GgaAffx.6286.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016228
Ensembl peptide - ENSGALP00000050988
Ensembl peptide - ENSGALP00000044951
NCBI entrez gene - 421409     See in Manteia.
RefSeq - XM_015283823
RefSeq - XM_419464
swissprot - A0A1D5PDZ0
swissprot - A0A1D5NX58
swissprot - F1NG47
Ensembl - ENSGALG00000010000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkceaENSDARG00000003008Danio rerio
 prkcebENSDARG00000069928Danio rerio
 PRKCEENSG00000171132Homo sapiens
 PrkceENSMUSG00000045038Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188958
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794345
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595045
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497043
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201642
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127034
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936433
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408127
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162027
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357026
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397125
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050996 positive regulation of lipid catabolic process IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070257 positive regulation of mucus secretion IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2001031 positive regulation of cellular glucuronidation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0004699 calcium-independent protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030546 receptor activator activity IEA
 molecular_functionGO:0035276 ethanol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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