ENSGALG00000011889


Gallus gallus

Features
Gene ID: ENSGALG00000011889
  
Biological name :PRKCH
  
Synonyms : PRKCH / protein kinase C eta
  
Possible biological names infered from orthology : P23298 / P24723
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 54123881
Gene end: 54228128
  
Corresponding Affymetrix probe sets: Gga.8329.1.S1_at (Chicken Array)   GgaAffx.23696.1.S1_s_at (Chicken Array)   GgaAffx.7559.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019373
NCBI entrez gene - 423518     See in Manteia.
RefSeq - XM_015287908
RefSeq - XM_421417
swissprot - F1NJH1
Ensembl - ENSGALG00000011889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkchaENSDARG00000018382Danio rerio
 prkchbENSDARG00000043243Danio rerio
 PRKCHENSG00000027075Homo sapiens
 PrkchENSMUSG00000021108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000051
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497039
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201638
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595036
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794336
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936430
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127030
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357024
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162024
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408124
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397122
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IEA
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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