ENSGALG00000001270


Gallus gallus

Features
Gene ID: ENSGALG00000001270
  
Biological name :PRKCZ
  
Synonyms : PRKCZ / protein kinase C zeta
  
Possible biological names infered from orthology : Q02956 / Q05513
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 1792970
Gene end: 1832353
  
Corresponding Affymetrix probe sets: GgaAffx.23693.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001936
Ensembl peptide - ENSGALP00000049114
NCBI entrez gene - 419399     See in Manteia.
RefSeq - XM_004947394
RefSeq - XM_015297105
RefSeq - XM_015297106
RefSeq - XM_417561
swissprot - E1BQN6
swissprot - A0A1D5P8R5
Ensembl - ENSGALG00000001270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkczENSDARG00000043332Danio rerio
 PRKCZENSG00000067606Homo sapiens
 PrkczENSMUSG00000029053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936473
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000038
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188938
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595036
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794335
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497035
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201634
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357029
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162028
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397127
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408127
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR012233  Protein kinase C
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:1990138 neuron projection extension IEA
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IEA
 biological_processGO:2000664 positive regulation of interleukin-5 secretion IEA
 biological_processGO:2000667 positive regulation of interleukin-13 secretion IEA
 biological_processGO:2001181 positive regulation of interleukin-10 secretion IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0043203 axon hillock IEA
 cellular_componentGO:0045179 apical cortex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction
 ENSGALG00000001214 PARD6A / par-6 family cell polarity regulator alpha / Q9NPB6* / Q9Z101* / Partitioning defective 6 homolog alpha *  / complex
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction






 

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