ENSG00000067606


Homo sapiens

Features
Gene ID: ENSG00000067606
  
Biological name :PRKCZ
  
Synonyms : PRKCZ / protein kinase C zeta / Q05513
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.33
Gene start: 2050470
Gene end: 2185395
  
Corresponding Affymetrix probe sets: 202178_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421869
Ensembl peptide - ENSP00000421587
Ensembl peptide - ENSP00000422349
Ensembl peptide - ENSP00000462105
Ensembl peptide - ENSP00000427134
Ensembl peptide - ENSP00000427085
Ensembl peptide - ENSP00000426412
Ensembl peptide - ENSP00000425643
Ensembl peptide - ENSP00000425317
Ensembl peptide - ENSP00000424945
Ensembl peptide - ENSP00000424763
Ensembl peptide - ENSP00000424398
Ensembl peptide - ENSP00000424228
Ensembl peptide - ENSP00000422764
Ensembl peptide - ENSP00000367830
Ensembl peptide - ENSP00000383712
Ensembl peptide - ENSP00000421219
Ensembl peptide - ENSP00000421350
NCBI entrez gene - 5590     See in Manteia.
OMIM - 176982
RefSeq - XM_017001805
RefSeq - NM_002744
RefSeq - XM_011541773
RefSeq - XM_011541774
RefSeq - XM_011541776
RefSeq - XM_011541778
RefSeq - XM_017001789
RefSeq - XM_017001790
RefSeq - XM_017001791
RefSeq - XM_017001792
RefSeq - XM_017001793
RefSeq - XM_017001794
RefSeq - XM_017001795
RefSeq - XM_017001796
RefSeq - XM_017001797
RefSeq - XM_017001798
RefSeq - XM_017001799
RefSeq - XM_017001800
RefSeq - XM_017001801
RefSeq - XM_017001802
RefSeq - XM_017001804
RefSeq - NM_001033581
RefSeq - NM_001033582
RefSeq - NM_001242874
RefSeq Peptide - NP_001229803
RefSeq Peptide - NP_002735
RefSeq Peptide - NP_001028753
RefSeq Peptide - NP_001028754
swissprot - D6REZ8
swissprot - D6RDM0
swissprot - D6RD31
swissprot - D6RCN4
swissprot - D6RC84
swissprot - D6RBD4
swissprot - E9PBE1
swissprot - F2Z2H9
swissprot - F2Z3C5
swissprot - J3KRP7
swissprot - Q05513
swissprot - D6RAN5
swissprot - D6RAU1
swissprot - D6RJG4
swissprot - D6RGG1
swissprot - D6RG01
Ensembl - ENSG00000067606
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkczENSDARG00000043332Danio rerio
 PRKCZENSGALG00000001270Gallus gallus
 PrkczENSMUSG00000029053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCI / P41743 / protein kinase C iotaENSG0000016355872
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113239
PRKCH / P24723 / protein kinase C etaENSG0000002707537
PRKCA / P17252 / protein kinase C alphaENSG0000015422936
PRKCB / P05771 / protein kinase C betaENSG0000016650135
PRKCD / Q05655 / protein kinase C deltaENSG0000016393234
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567534
PRKCG / P05129 / protein kinase C gammaENSG0000012658334
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220829
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420529
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522128
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851528
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702027
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012233  Protein kinase C
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034662  Atypical Protein Kinase C zeta, catalytic domain
 IPR034877  Protein kinase C, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030010 establishment of cell polarity ISS
 biological_processGO:0031333 negative regulation of protein complex assembly IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0031584 activation of phospholipase D activity IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production ISS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation ISS
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway ISS
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051222 positive regulation of protein transport IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:1990138 neuron projection extension IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production ISS
 biological_processGO:2000664 positive regulation of interleukin-5 secretion ISS
 biological_processGO:2000667 positive regulation of interleukin-13 secretion ISS
 biological_processGO:2001181 positive regulation of interleukin-10 secretion ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030054 cell junction TAS
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0043203 axon hillock IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045179 apical cortex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IC
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction / complex
 ENSG00000102981 PARD6A / Q9NPB6 / par-6 family cell polarity regulator alpha  / complex
 ENSG00000148498 PARD3 / Q8TEW0 / par-3 family cell polarity regulator  / complex
 ENSG00000176170 SPHK1 / Q9NYA1 / sphingosine kinase 1  / reaction






 

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