ENSG00000171132


Homo sapiens

Features
Gene ID: ENSG00000171132
  
Biological name :PRKCE
  
Synonyms : PRKCE / protein kinase C epsilon / Q02156
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p21
Gene start: 45651345
Gene end: 46187990
  
Corresponding Affymetrix probe sets: 206248_at (Human Genome U133 Plus 2.0 Array)   226101_at (Human Genome U133 Plus 2.0 Array)   236459_at (Human Genome U133 Plus 2.0 Array)   239011_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378341
Ensembl peptide - ENSP00000394574
Ensembl peptide - ENSP00000306124
NCBI entrez gene - 5581     See in Manteia.
OMIM - 176975
RefSeq - XM_017004492
RefSeq - XM_017004487
RefSeq - XM_017004488
RefSeq - XM_017004489
RefSeq - XM_017004490
RefSeq - XM_017004491
RefSeq - NM_005400
RefSeq - XM_005264428
RefSeq - XM_005264431
RefSeq - XM_011532971
RefSeq - XM_011532975
RefSeq - XM_011532978
RefSeq - XM_011532980
RefSeq - XM_011532981
RefSeq - XM_011532982
RefSeq - XM_017004486
RefSeq Peptide - NP_005391
swissprot - E9PBI2
swissprot - L7RTI5
swissprot - C9JR22
swissprot - Q02156
Ensembl - ENSG00000171132
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkceaENSDARG00000003008Danio rerio
 prkcebENSDARG00000069928Danio rerio
 PRKCEENSGALG00000010000Gallus gallus
 PrkceENSMUSG00000045038Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCH / P24723 / protein kinase C etaENSG0000002707560
PRKCA / P17252 / protein kinase C alphaENSG0000015422941
PRKCB / P05771 / protein kinase C betaENSG0000016650140
PRKCD / Q05655 / protein kinase C deltaENSG0000016393240
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567539
PRKCG / P05129 / protein kinase C gammaENSG0000012658338
PRKCI / P41743 / protein kinase C iotaENSG0000016355831
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760631
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220825
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702025
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420524
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851524
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522124
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027274  Protein kinase C, epsilon
 IPR034669  Novel protein kinase C epsilon, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010763 positive regulation of fibroblast migration ISS
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISS
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway ISS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050996 positive regulation of lipid catabolic process IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070257 positive regulation of mucus secretion IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090303 positive regulation of wound healing IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane TAS
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity TAS
 biological_processGO:2001031 positive regulation of cellular glucuronidation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003785 actin monomer binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004697 protein kinase C activity IDA
 molecular_functionGO:0004699 calcium-independent protein kinase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity IMP
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0030546 receptor activator activity IEA
 molecular_functionGO:0035276 ethanol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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