ENSG00000104205


Homo sapiens

Features
Gene ID: ENSG00000104205
  
Biological name :SGK3
  
Synonyms : Q96BR1 / serum/glucocorticoid regulated kinase family member 3 / SGK3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q13.1
Gene start: 66667596
Gene end: 66862022
  
Corresponding Affymetrix probe sets: 220038_at (Human Genome U133 Plus 2.0 Array)   227627_at (Human Genome U133 Plus 2.0 Array)   243264_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428529
Ensembl peptide - ENSP00000428972
Ensembl peptide - ENSP00000430691
Ensembl peptide - ENSP00000430475
Ensembl peptide - ENSP00000430463
Ensembl peptide - ENSP00000430256
Ensembl peptide - ENSP00000429606
Ensembl peptide - ENSP00000429565
Ensembl peptide - ENSP00000429022
Ensembl peptide - ENSP00000331816
Ensembl peptide - ENSP00000379842
NCBI entrez gene - 100533105     See in Manteia.
NCBI entrez gene - 23678     See in Manteia.
OMIM - 607591
RefSeq - NM_170709
RefSeq - NM_013257
RefSeq - NM_001033578
RefSeq - NM_001204173
RefSeq Peptide - NP_733827
RefSeq Peptide - NP_001028750
RefSeq Peptide - NP_001191102
RefSeq Peptide - NP_037389
swissprot - Q96BR1
swissprot - E5RJV7
swissprot - E5RHY6
swissprot - E5RHX2
swissprot - E5RHR8
swissprot - A0A024R807
swissprot - E5RK28
Ensembl - ENSG00000104205
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgk3ENSDARG00000062460Danio rerio
 SGK3ENSGALG00000043570Gallus gallus
 Sgk3ENSMUSG00000025915Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851560
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104951
PRKCH / P24723 / protein kinase C etaENSG0000002707535
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113235
PRKCI / P41743 / protein kinase C iotaENSG0000016355835
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760635
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220834
PRKCD / Q05655 / protein kinase C deltaENSG0000016393234
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522134
PRKCA / P17252 / protein kinase C alphaENSG0000015422934
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702034
PRKCG / P05129 / protein kinase C gammaENSG0000012658333
PRKCB / P05771 / protein kinase C betaENSG0000016650133
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567533


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001683  Phox homologous domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030334 regulation of cell migration TAS
 biological_processGO:0032411 positive regulation of transporter activity IBA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005246 calcium channel regulator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity TAS
 molecular_functionGO:0017081 chloride channel regulator activity TAS
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex
 ENSG00000049759 NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  / complex
 ENSG00000123124 WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1  / complex
 ENSG00000157514 Q99576 / TSC22D3 / TSC22 domain family member 3  / complex






 

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