ENSG00000163932


Homo sapiens

Features
Gene ID: ENSG00000163932
  
Biological name :PRKCD
  
Synonyms : PRKCD / protein kinase C delta / Q05655
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.1
Gene start: 53156009
Gene end: 53192717
  
Corresponding Affymetrix probe sets: 202545_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419726
Ensembl peptide - ENSP00000418106
Ensembl peptide - ENSP00000331602
Ensembl peptide - ENSP00000378217
Ensembl peptide - ENSP00000419629
NCBI entrez gene - 5580     See in Manteia.
OMIM - 176977
RefSeq - XM_017006856
RefSeq - NM_001316327
RefSeq - NM_006254
RefSeq - NM_212539
RefSeq - XM_006713257
RefSeq - XM_006713259
RefSeq - XM_017006855
RefSeq Peptide - NP_001341609
RefSeq Peptide - NP_006245
RefSeq Peptide - NP_997704
RefSeq Peptide - NP_001341608
RefSeq Peptide - NP_001303256
swissprot - A0A024R328
swissprot - C9K0E3
swissprot - C9JZU8
swissprot - C9J9P1
swissprot - Q05655
Ensembl - ENSG00000163932
  
Related genetic diseases (OMIM): 615559 - Autoimmune lymphoproliferative syndrome, type III, 615559
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcdaENSDARG00000009208Danio rerio
 prkcdbENSDARG00000070651Danio rerio
 PRKCDENSGALG00000002016Gallus gallus
 PrkcdENSMUSG00000021948Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567565
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113243
PRKCH / P24723 / protein kinase C etaENSG0000002707542
PRKCB / P05771 / protein kinase C betaENSG0000016650141
PRKCA / P17252 / protein kinase C alphaENSG0000015422939
PRKCG / P05129 / protein kinase C gammaENSG0000012658339
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760630
PRKCI / P41743 / protein kinase C iotaENSG0000016355829
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702027
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851526
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522126
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220826
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420525
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027436  Protein kinase C, delta
 IPR034667  Novel protein kinase C delta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress TAS
 biological_processGO:0010469 regulation of signaling receptor activity TAS
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023021 termination of signal transduction IMP
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030837 negative regulation of actin filament polymerization ISS
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IMP
 biological_processGO:0032091 negative regulation of protein binding TAS
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032613 interleukin-10 production IEA
 biological_processGO:0032615 interleukin-12 production IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IMP
 biological_processGO:0035307 positive regulation of protein dephosphorylation IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus IMP
 biological_processGO:0042742 defense response to bacterium ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway TAS
 biological_processGO:0050728 negative regulation of inflammatory response IC
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050821 protein stabilization NAS
 biological_processGO:0051490 negative regulation of filopodium assembly ISS
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071447 cellular response to hydroperoxide IDA
 biological_processGO:0090331 negative regulation of platelet aggregation ISS
 biological_processGO:0090398 cellular senescence IMP
 biological_processGO:0097194 execution phase of apoptosis TAS
 biological_processGO:1900163 positive regulation of phospholipid scramblase activity IMP
 biological_processGO:1904385 cellular response to angiotensin IDA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process IMP
 biological_processGO:2000753 positive regulation of glucosylceramide catabolic process IMP
 biological_processGO:2000755 positive regulation of sphingomyelin catabolic process IMP
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IMP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004697 protein kinase C activity TAS
 molecular_functionGO:0004699 calcium-independent protein kinase C activity EXP
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043560 insulin receptor substrate binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Neutrophil degranulation
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000100 Nephrotic syndrome 
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 HP:0000248 Brachycephaly "Brachycephaly refers to a short, wide head, which is often caused by premature closure of both coronal sutures." [HPO:curators]
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 HP:0000389 Chronic otitis media 
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 HP:0000979 Purpura 
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 HP:0001531 Failure to thrive in infancy 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001878 Hemolytic anemia 
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 HP:0001888 Lymphopenia 
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 HP:0001973 Immune thrombocytopenia 
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 HP:0002023 Anal atresia "Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract." [HPO:curators]
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 HP:0002090 Pneumonia 
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 HP:0002091 Restrictive lung disease 
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 HP:0002097 Emphysema 
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 HP:0002110 Bronchiectasis 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002633 Vasculitis 
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 HP:0002665 Lymphoma "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." [HPO:curators]
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 HP:0002716 Lymphadenopathy 
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 HP:0002719 Recurrent infections 
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 HP:0002721 Immunodeficiency 
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 HP:0002829 Arthralgia 
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 HP:0002837 Bronchitis 
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 HP:0002910 Elevated transaminases "Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." [HPO:curators]
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 HP:0003593 Early onset 
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 HP:0004313 Reduced immunoglobulin levels 
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 HP:0006783 Posterior pharyngeal cleft 
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 HP:0012578 Membranous nephropathy "A type of glomerulonephropathy characterized by thickening of the basement membrane and deposition of immune complexes in the subepithelial space." [Eurenomics:fschaefer]
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 HP:0100723 Gastrointestinal stroma tumor 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000173020 GRK2 / P25098 / G protein-coupled receptor kinase 2  / reaction
 ENSG00000187796 CARD9 / Q9H257 / caspase recruitment domain family member 9  / reaction
 ENSG00000176170 SPHK1 / Q9NYA1 / sphingosine kinase 1  / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / reaction
 ENSG00000066044 ELAVL1 / Q15717 / ELAV like RNA binding protein 1  / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / reaction






 

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