ENSG00000118515


Homo sapiens

Features
Gene ID: ENSG00000118515
  
Biological name :SGK1
  
Synonyms : O00141 / serum/glucocorticoid regulated kinase 1 / SGK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.2
Gene start: 134169246
Gene end: 134318112
  
Corresponding Affymetrix probe sets: 201739_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434302
Ensembl peptide - ENSP00000434450
Ensembl peptide - ENSP00000436470
Ensembl peptide - ENSP00000435724
Ensembl peptide - ENSP00000435577
Ensembl peptide - ENSP00000237305
Ensembl peptide - ENSP00000356831
Ensembl peptide - ENSP00000356832
Ensembl peptide - ENSP00000396242
Ensembl peptide - ENSP00000431705
NCBI entrez gene - 6446     See in Manteia.
OMIM - 602958
RefSeq - XM_011536071
RefSeq - NM_001143676
RefSeq - NM_001143677
RefSeq - NM_001143678
RefSeq - NM_001291995
RefSeq - NM_005627
RefSeq Peptide - NP_005618
RefSeq Peptide - NP_001137148
RefSeq Peptide - NP_001137149
RefSeq Peptide - NP_001137150
RefSeq Peptide - NP_001278924
swissprot - O00141
swissprot - E9PP33
swissprot - Q7Z3I4
swissprot - E9PR89
swissprot - E9PJN2
swissprot - H0YCJ3
Ensembl - ENSG00000118515
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgk1ENSDARG00000025522Danio rerio
 SGK1ENSGALG00000013971Gallus gallus
 Sgk1ENSMUSG00000019970Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420556
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104951
PRKCD / Q05655 / protein kinase C deltaENSG0000016393234
PRKCH / P24723 / protein kinase C etaENSG0000002707534
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702034
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522133
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567533
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113233
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220833
PRKCA / P17252 / protein kinase C alphaENSG0000015422932
PRKCG / P05129 / protein kinase C gammaENSG0000012658332
PRKCI / P41743 / protein kinase C iotaENSG0000016355831
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760631
PRKCB / P05771 / protein kinase C betaENSG0000016650131


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001683  Phox homologous domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006814 sodium ion transport TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007616 long-term memory TAS
 biological_processGO:0008217 regulation of blood pressure TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030334 regulation of cell migration TAS
 biological_processGO:0032411 positive regulation of transporter activity TAS
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0050790 regulation of catalytic activity TAS
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0060453 regulation of gastric acid secretion TAS
 biological_processGO:0070294 renal sodium ion absorption TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005246 calcium channel regulator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity TAS
 molecular_functionGO:0017081 chloride channel regulator activity TAS
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex
 ENSG00000049759 NEDD4L / Q96PU5 / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  / complex
 ENSG00000123124 WWP1 / Q9H0M0 / WW domain containing E3 ubiquitin protein ligase 1  / complex
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000157514 Q99576 / TSC22D3 / TSC22 domain family member 3  / complex
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction






 

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