ENSDARG00000025522


Danio rerio

Features
Gene ID: ENSDARG00000025522
  
Biological name :sgk1
  
Synonyms : Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / sgk1
  
Possible biological names infered from orthology : O00141 / Q9WVC6 / Serine/threonine-protein kinase Sgk1
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 31640239
Gene end: 31693309
  
Corresponding Affymetrix probe sets: Dr.10320.1.S1_at (Zebrafish Array)   NM_199212_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000031762
Ensembl peptide - ENSDARP00000121789
Ensembl peptide - ENSDARP00000120935
Ensembl peptide - ENSDARP00000118538
NCBI entrez gene - 324140     See in Manteia.
RefSeq - NM_199212
RefSeq - XM_005162300
RefSeq - XM_005162301
RefSeq Peptide - NP_954682
swissprot - E9QIF7
swissprot - E9QI98
swissprot - E9QEW2
swissprot - Q7ZTW4
ZFIN ID - ZDB-GENE-030131-2860
Ensembl - ENSDARG00000025522
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SGK1ENSGALG00000013971Gallus gallus
 SGK1ENSG00000118515Homo sapiens
 Sgk1ENSMUSG00000019970Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-195b13.1ENSDARG0000001662368
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246064
sgk2a / serum/glucocorticoid regulated kinase 2a / SGK2* / Q9QZS5* / Q9HBY8* / SGK2, serine/threonine kinase 2* / Serine/threonine-protein kinase Sgk2 *ENSDARG0000006337060
sgk2b / serum/glucocorticoid regulated kinase 2bENSDARG0000000659850
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481040
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361240
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121940
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324339
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992839
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720539
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838238
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300838
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565737
PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*ENSDARG0000009984136
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122536
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065136
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456136
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417336
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333236
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872336


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001683  Phox homologous domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / reaction






 

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