ENSDARG00000021225


Danio rerio

Features
Gene ID: ENSDARG00000021225
  
Biological name :prkci
  
Synonyms : prkci / protein kinase C, iota / Q90XF2
  
Possible biological names infered from orthology : P41743 / Q62074
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 37365551
Gene end: 37401600
  
Corresponding Affymetrix probe sets: Dr.2532.1.S1_at (Zebrafish Array)   NM_131855_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000005309
NCBI entrez gene - 117507     See in Manteia.
RefSeq - NM_131855
RefSeq Peptide - NP_571930
swissprot - Q90XF2
ZFIN ID - ZDB-GENE-011105-1
Ensembl - ENSDARG00000021225
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKCIENSGALG00000009364Gallus gallus
 PRKCIENSG00000163558Homo sapiens
 PrkciENSMUSG00000037643Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333271
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300839
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992838
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838236
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565735
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225435
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324335
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417334
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872334
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456134
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065133
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920833
PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*ENSDARG0000009984132
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720528
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481028
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361228
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121928
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246027
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552227
si:ch211-195b13.1ENSDARG0000001662326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011009  Protein kinase-like domain superfamily
 IPR012233  Protein kinase C
 IPR017892  Protein kinase, C-terminal
 IPR034661  Atypical protein kinase C iota type, catalytic domain
 IPR034877  Protein kinase C, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0001738 morphogenesis of a polarized epithelium IMP
 biological_processGO:0001841 neural tube formation IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007097 nuclear migration IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007502 digestive tract mesoderm development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008078 mesodermal cell migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016332 establishment or maintenance of polarity of embryonic epithelium IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0021744 dorsal motor nucleus of vagus nerve development IMP
 biological_processGO:0030031 cell projection assembly IMP
 biological_processGO:0034332 adherens junction organization IMP
 biological_processGO:0034334 adherens junction maintenance IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0035778 pronephric nephron tubule epithelial cell differentiation IGI
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0045216 cell-cell junction organization ISS
 biological_processGO:0045217 cell-cell junction maintenance IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005915 zonula adherens IDA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISS
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
brain shape , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle dilated , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer disorganized , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type oligodendrocyte , abnormal
spinal cord has fewer parts of type radial glial cell , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle decreased diameter , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
heart quality , abnormal
heart decreased size , abnormal
heart dense , abnormal
heart morphology , abnormal
heart disorganized , abnormal
Show

 ZFA:0000123 liver liver morphology , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium quality , abnormal
retinal pigmented epithelium structure , abnormal
retinal pigmented epithelium morphology , abnormal
retinal pigmented epithelium patchy , abnormal
retinal pigmented epithelium poorly differentiated , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct early endosome absent , abnormal
Show

 ZFA:0000151 pronephros pronephros quality , abnormal
Show

 ZFA:0000152 retina retina neuroepithelial cell positional polarity , abnormal
retina has fewer parts of type retinal rod cell , abnormal
retina degenerate , abnormal
retina quality , abnormal
retina structure , abnormal
retina unstratified , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000471 atrium atrium dilated , abnormal
atrium aplastic , abnormal
Show

 ZFA:0000640 cornea cornea structure , abnormal
cornea anatomical surface structure , abnormal
Show

 ZFA:0000938 central canal central canal increased size , abnormal
central canal malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
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 ZFA:0001114 head head decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region curved dorsal , abnormal
Show

 ZFA:0001135 neural tube neural tube malformed , abnormal
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 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone decreased length , abnormal
ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth , abnormal
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 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
ventricular system structure, cavities , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule malformed , abnormal
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 ZFA:0001673 pronephric podocyte pronephric podocyte mislocalised laterally , abnormal
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 ZFA:0001683 corneal epithelium corneal epithelium saccular , abnormal
corneal epithelium desmosome decreased amount , abnormal
Show

 ZFA:0001685 corneal stroma corneal stroma disorganized , abnormal
Show

 ZFA:0001695 dorsolateral motor nucleus of vagal nerve dorsolateral motor nucleus of vagal nerve malformed , abnormal
Show

 ZFA:0009011 neuroblast neuroblast nucleus position , abnormal
Show

 ZFA:0009041 peridermal cell peridermal cell actin-based cell projection increased length , abnormal
peridermal cell actin-based cell projection decreased length , abnormal
peridermal cell apical side increased amount , abnormal
peridermal cell apical side decreased amount , abnormal
peridermal cell actin-based cell projection length , ameliorated
peridermal cell actin-based cell projection increased amount , abnormal
peridermal cell actin-based cell projection decreased amount , abnormal
Show

 ZFA:0009091 melanocyte melanocyte quality , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell apical region decreased length , abnormal
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 ZFA:0009241 pigmented epithelial cell pigmented epithelial cell shape , abnormal
pigmented epithelial cell pigment granule mislocalised , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell spatial pattern , abnormal
Show

 ZFA:0009264 corneal epithelial cell corneal epithelial cell cellular adhesivity corneal epithelial cell , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell cell-cell junction broken , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017320 f11r.1 / F11 receptor, tandem duplicate 1 / F11R* / O88792* / Q9Y624* / F11 receptor* / Junctional adhesion molecule A *  / reaction / complex
 ENSDARG00000068114 f11r.2 / F11 receptor, tandem duplicate 2 / F11R* / O88792* / Q9Y624* / F11 receptor* / Junctional adhesion molecule A *  / reaction / complex
 ENSDARG00000077982 elf3 / E74-like factor 3 (ets domain transcription factor, epithelial-specific ) / P78545* / Q3UPW2* / E74 like ETS transcription factor 3* / ETS-related transcription factor Elf-3 *  / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000075014 sqstm1 / sequestosome 1 / Q13501* / Q64337*  / complex / reaction
 ENSDARG00000025949 irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*  / complex / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction / complex






 

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