ENSDARG00000008723


Danio rerio

Features
Gene ID: ENSDARG00000008723
  
Biological name :prkcba
  
Synonyms : prkcba / protein kinase C, beta a
  
Possible biological names infered from orthology : P05771 / P68404 / PRKCB / protein kinase C beta
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 9004719
Gene end: 9064912
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000121846
Ensembl peptide - ENSDARP00000024929
NCBI entrez gene - 100006675     See in Manteia.
RefSeq - NM_201029
RefSeq Peptide - NP_957323
swissprot - E9QEK0
swissprot - Q7T2C5
ZFIN ID - ZDB-GENE-040426-1354
Ensembl - ENSDARG00000008723
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKCBENSGALG00000037943Gallus gallus
 PRKCBENSG00000166501Homo sapiens
 PrkcbENSMUSG00000052889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225482
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565773
PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*ENSDARG0000009984166
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456163
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992843
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300843
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920841
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417340
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838240
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065140
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324339
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333231
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122530
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121926
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481026
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720526
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361226
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246024
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552223
si:ch211-195b13.1ENSDARG0000001662321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction
 ENSDARG00000052518 stx4 / syntaxin 4 / Stx4a* / P70452* / Q12846*  / reaction






 

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