ENSDARG00000011219


Danio rerio

Features
Gene ID: ENSDARG00000011219
  
Biological name :akt2
  
Synonyms : akt2 / v-akt murine thymoma viral oncogene homolog 2
  
Possible biological names infered from orthology : AKT serine/threonine kinase 2 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751 / Q60823
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 40711188
Gene end: 40753583
  
Corresponding Affymetrix probe sets: DrAffx.1.41.S1_at (Zebrafish Array)   NM_198146_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000023119
NCBI entrez gene - 378972     See in Manteia.
RefSeq - NM_198146
RefSeq Peptide - NP_937789
swissprot - Q8UUX0
ZFIN ID - ZDB-GENE-031007-5
Ensembl - ENSDARG00000011219
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKT2ENSG00000105221Homo sapiens
 Akt2ENSMUSG00000004056Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361282
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720577
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481077
akt1 / v-akt murine thymoma viral oncogene homolog 1 / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSDARG0000009965742
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838239
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065138
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565737
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992837
si:ch211-195b13.1ENSDARG0000001662337
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225437
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417337
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300837
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324337
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920836
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552236
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456136
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872336
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246035
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333235
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122534


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR034677  Protein Kinase B beta, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0060348 bone development IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Activation of AKT2
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood glucose increased amount , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000114 heart heart decreased amount , abnormal
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 ZFA:0000123 liver liver decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism viability , abnormal
whole organism decreased weight , abnormal
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001114 head head opaque , abnormal
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 ZFA:0005145 muscle muscle decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction
 ENSDARG00000061621 them4 / thioesterase superfamily member 4 / THEM5* / Q8N1Q8* / Q9CQJ0* / Q5T1C6* / Q3UUI3* / thioesterase superfamily member 5* / Acyl-coenzyme A thioesterase THEM4 *  / complex
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / reaction






 

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