ENSDARG00000104810


Danio rerio

Features
Gene ID: ENSDARG00000104810
  
Biological name :akt3a
  
Synonyms : akt3a / v-akt murine thymoma viral oncogene homolog 3a
  
Possible biological names infered from orthology : AKT3 / AKT serine/threonine kinase 3 / Q9WUA6 / Q9Y243 / RAC-gamma serine/threonine-protein kinase
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 11175208
Gene end: 11378355
  
Corresponding Affymetrix probe sets: Dr.18229.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000131746
Ensembl peptide - ENSDARP00000139879
NCBI entrez gene - 560549     See in Manteia.
swissprot - A0A0R4IF30
swissprot - D9IL79
ZFIN ID - ZDB-GENE-050419-180
Ensembl - ENSDARG00000104810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKT3ENSGALG00000034081Gallus gallus
 AKT3ENSG00000117020Homo sapiens
 Akt3ENSMUSG00000019699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720595
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121977
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361276
akt1 / v-akt murine thymoma viral oncogene homolog 1 / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSDARG0000009965744
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838239
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992839
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300839
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065139
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565738
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920838
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324338
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456137
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872337
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417337
prkcbb / Q7SY24 / protein kinase C, beta b / PRKCB* / P05771* / protein kinase C beta*ENSDARG0000002225437
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552236
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246036
si:ch211-195b13.1ENSDARG0000001662336
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122535
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR034675  Protein kinase B gamma, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr