ENSDARG00000022254


Danio rerio

Features
Gene ID: ENSDARG00000022254
  
Biological name :prkcbb
  
Synonyms : prkcbb / protein kinase C, beta b / Q7SY24
  
Possible biological names infered from orthology : P05771 / P68404 / PRKCB / protein kinase C beta
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 35005062
Gene end: 35266060
  
Corresponding Affymetrix probe sets: Dr.15087.1.A1_at (Zebrafish Array)   NM_200978_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000038918
Ensembl peptide - ENSDARP00000155856
NCBI entrez gene - 393953     See in Manteia.
RefSeq - NM_200978
RefSeq Peptide - NP_957272
swissprot - Q7SY24
ZFIN ID - ZDB-GENE-040426-1178
Ensembl - ENSDARG00000022254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKCBENSGALG00000037943Gallus gallus
 PRKCBENSG00000166501Homo sapiens
 PrkcbENSMUSG00000052889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkcba / protein kinase C, beta a / PRKCB* / P68404* / P05771* / protein kinase C beta*ENSDARG0000000872381
prkca / protein kinase C, alpha / P17252*ENSDARG0000011565777
PRKCA / si:ch73-374l24.1 / si:ch1073-370j18.1 / P17252* / protein kinase C alpha*ENSDARG0000009984170
prkcg / protein kinase C, gamma / P05129* / P63318*ENSDARG0000000456166
prkcea / protein kinase C, epsilon a / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000000300844
prkceb / protein kinase C, epsilon b / PRKCE* / P16054* / Q02156* / protein kinase C epsilon*ENSDARG0000006992844
prkcq / protein kinase C, theta / Q02111* / Q04759*ENSDARG0000003417341
prkcdb / protein kinase C, delta b / PRKCD* / Q05655* / protein kinase C delta*ENSDARG0000007065141
prkcda / protein kinase C, delta a / PRKCD* / P28867* / Q05655* / protein kinase C delta*ENSDARG0000000920841
prkcha / protein kinase C, eta, a / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000001838241
prkchb / protein kinase C, eta, b / PRKCH* / P24723* / P23298* / protein kinase C eta*ENSDARG0000004324340
prkci / Q90XF2 / protein kinase C, iota / P41743* / Q62074*ENSDARG0000002122531
prkcz / protein kinase C, zeta / Q02956* / Q05513*ENSDARG0000004333231
akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*ENSDARG0000001121927
akt3a / v-akt murine thymoma viral oncogene homolog 3a / AKT3* / Q9WUA6* / Q9Y243* / AKT serine/threonine kinase 3* / RAC-gamma serine/threonine-protein kinase *ENSDARG0000010481027
akt3b / v-akt murine thymoma viral oncogene homolog 3bENSDARG0000008720526
akt2l / v-akt murine thymoma viral oncogene homolog 2, like / AKT2* / P31751* / AKT serine/threonine kinase 2*ENSDARG0000010361226
sgk3 / serum/glucocorticoid regulated kinase family, member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSDARG0000006246024
sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *ENSDARG0000002552223
si:ch211-195b13.1ENSDARG0000001662322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR034664  Classical Protein Kinase C beta, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035408 histone H3-T6 phosphorylation ISS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042113 B cell activation ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0050853 B cell receptor signaling pathway ISS
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISS
 molecular_functionGO:0035403 histone kinase activity (H3-T6 specific) ISS
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding ISS


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0001114 head head apoptotic , abnormal
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte cellular adhesivity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction
 ENSDARG00000052518 stx4 / syntaxin 4 / Stx4a* / P70452* / Q12846*  / reaction






 

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