ENSG00000166501


Homo sapiens

Features
Gene ID: ENSG00000166501
  
Biological name :PRKCB
  
Synonyms : P05771 / PRKCB / protein kinase C beta
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.2
Gene start: 23835946
Gene end: 24220611
  
Corresponding Affymetrix probe sets: 207957_s_at (Human Genome U133 Plus 2.0 Array)   209685_s_at (Human Genome U133 Plus 2.0 Array)   227817_at (Human Genome U133 Plus 2.0 Array)   227824_at (Human Genome U133 Plus 2.0 Array)   228795_at (Human Genome U133 Plus 2.0 Array)   230437_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000493817
Ensembl peptide - ENSP00000496129
Ensembl peptide - ENSP00000305355
Ensembl peptide - ENSP00000318315
Ensembl peptide - ENSP00000457980
Ensembl peptide - ENSP00000458564
Ensembl peptide - ENSP00000459227
NCBI entrez gene - 5579     See in Manteia.
OMIM - 176970
RefSeq - NM_212535
RefSeq - NM_002738
RefSeq Peptide - NP_002729
RefSeq Peptide - NP_997700
swissprot - P05771
swissprot - I3L148
swissprot - I3L1Z0
swissprot - H3BV73
Ensembl - ENSG00000166501
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcbaENSDARG00000008723Danio rerio
 prkcbbENSDARG00000022254Danio rerio
 PRKCBENSGALG00000037943Gallus gallus
 PrkcbENSMUSG00000052889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCA / P17252 / protein kinase C alphaENSG0000015422980
PRKCG / P05129 / protein kinase C gammaENSG0000012658371
PRKCE / Q02156 / protein kinase C epsilonENSG0000017113244
PRKCQ / Q04759 / protein kinase C thetaENSG0000006567541
PRKCH / P24723 / protein kinase C etaENSG0000002707541
PRKCD / Q05655 / protein kinase C deltaENSG0000016393241
PRKCI / P41743 / protein kinase C iotaENSG0000016355832
PRKCZ / Q05513 / protein kinase C zetaENSG0000006760631
AKT1 / P31749 / AKT serine/threonine kinase 1ENSG0000014220827
AKT3 / Q9Y243 / AKT serine/threonine kinase 3ENSG0000011702027
AKT2 / P31751 / AKT serine/threonine kinase 2ENSG0000010522126
SGK3 / Q96BR1 / serum/glucocorticoid regulated kinase family member 3ENSG0000010420525
SGK1 / O00141 / serum/glucocorticoid regulated kinase 1ENSG0000011851524
SGK2 / Q9HBY8 / SGK2, serine/threonine kinase 2ENSG0000010104921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR030541  Rabphilin-1
 IPR034664  Classical Protein Kinase C beta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0010829 negative regulation of glucose transmembrane transport ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0035408 histone H3-T6 phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042113 B cell activation ISS
 biological_processGO:0042953 lipoprotein transport TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0045637 regulation of myeloid cell differentiation TAS
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0050853 B cell receptor signaling pathway ISS
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0071322 cellular response to carbohydrate stimulus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004697 protein kinase C activity TAS
 molecular_functionGO:0004698 calcium-dependent protein kinase C activity TAS
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005246 calcium channel regulator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IMP
 molecular_functionGO:0035403 histone kinase activity (H3-T6 specific) IDA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IDA


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000102119 EMD / emerin / P50402  / reaction
 ENSG00000176170 SPHK1 / Q9NYA1 / sphingosine kinase 1  / reaction
 ENSG00000160789 LMNA / P02545 / lamin A/C  / reaction
 ENSG00000116266 O00186 / STXBP3 / syntaxin binding protein 3  / reaction
 ENSG00000103496 STX4 / Q12846 / syntaxin 4  / reaction






 

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