ENSG00000103496


Homo sapiens

Features
Gene ID: ENSG00000103496
  
Biological name :STX4
  
Synonyms : Q12846 / STX4 / syntaxin 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 31032889
Gene end: 31042975
  
Corresponding Affymetrix probe sets: 203530_s_at (Human Genome U133 Plus 2.0 Array)   229395_at (Human Genome U133 Plus 2.0 Array)   236232_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454841
Ensembl peptide - ENSP00000390788
Ensembl peptide - ENSP00000480544
Ensembl peptide - ENSP00000454419
Ensembl peptide - ENSP00000317714
Ensembl peptide - ENSP00000378447
NCBI entrez gene - 6810     See in Manteia.
OMIM - 186591
RefSeq - XM_005255521
RefSeq - NM_001272095
RefSeq - NM_001272096
RefSeq - NM_004604
RefSeq Peptide - NP_001259025
RefSeq Peptide - NP_001259024
RefSeq Peptide - NP_004595
swissprot - Q12846
swissprot - A0A087WWW0
swissprot - C9JFM5
swissprot - H3BMK2
Ensembl - ENSG00000103496
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx4ENSDARG00000052518Danio rerio
 Stx4aENSMUSG00000030805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STX1B / P61266 / syntaxin 1BENSG0000009936546
STX1A / Q16623 / syntaxin 1AENSG0000010608944
STX2 / P32856 / syntaxin 2ENSG0000011145043
STX3 / Q13277 / syntaxin 3ENSG0000016690038
STX11 / O75558 / syntaxin 11ENSG0000013560427
STX19 / Q8N4C7 / syntaxin 19ENSG0000017875026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006892 post-Golgi vesicle-mediated transport TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017157 regulation of exocytosis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 biological_processGO:0033194 response to hydroperoxide IDA
 biological_processGO:0035493 SNARE complex assembly IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043311 positive regulation of eosinophil degranulation IMP
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0048284 organelle fusion IDA
 biological_processGO:0050921 positive regulation of chemotaxis IMP
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IMP
 biological_processGO:0060291 long-term synaptic potentiation IDA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane TAS
 biological_processGO:2000010 positive regulation of protein localization to cell surface IMP
 cellular_componentGO:0000322 storage vacuole IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005773 vacuole TAS
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0035749 myelin sheath adaxonal region IEA
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0042581 specific granule IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043219 lateral loop IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016230 sphingomyelin phosphodiesterase activator activity IMP


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
ER-Phagosome pathway
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Clathrin derived vesicle budding
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092531 O00161 / SNAP23 / synaptosome associated protein 23  / reaction / complex
 ENSG00000126583 PRKCG / P05129 / protein kinase C gamma  / reaction
 ENSG00000118640 VAMP8 / Q9BV40 / vesicle associated membrane protein 8  / complex / reaction
 ENSG00000166501 PRKCB / P05771 / protein kinase C beta  / reaction
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / complex
 ENSG00000124333 VAMP7 / P51809 / vesicle associated membrane protein 7  / complex / reaction
 ENSG00000220205 VAMP2 / P63027 / vesicle associated membrane protein 2  / reaction / complex
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction
 ENSG00000116266 O00186 / STXBP3 / syntaxin binding protein 3  / complex
 ENSG00000084652 TXLNA / P40222 / taxilin alpha  / complex / reaction






 

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