ENSG00000166900


Homo sapiens

Features
Gene ID: ENSG00000166900
  
Biological name :STX3
  
Synonyms : Q13277 / STX3 / syntaxin 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.1
Gene start: 59713456
Gene end: 59805882
  
Corresponding Affymetrix probe sets: 209238_at (Human Genome U133 Plus 2.0 Array)   216985_s_at (Human Genome U133 Plus 2.0 Array)   235483_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431386
Ensembl peptide - ENSP00000338562
Ensembl peptide - ENSP00000433248
Ensembl peptide - ENSP00000493027
Ensembl peptide - ENSP00000487790
Ensembl peptide - ENSP00000436200
Ensembl peptide - ENSP00000434836
NCBI entrez gene - 6809     See in Manteia.
OMIM - 600876
RefSeq - XM_017018196
RefSeq - XM_011545221
RefSeq - XM_017018188
RefSeq - XM_017018189
RefSeq - XM_017018190
RefSeq - XM_017018191
RefSeq - XM_017018192
RefSeq - XM_017018193
RefSeq - XM_017018194
RefSeq - XM_017018195
RefSeq - NM_001178040
RefSeq - NM_004177
RefSeq - XM_005274195
RefSeq - XM_005274198
RefSeq - XM_005274200
RefSeq Peptide - NP_004168
RefSeq Peptide - NP_001171511
swissprot - A0A286YF28
swissprot - A0A0J9YW33
swissprot - Q53YE2
swissprot - A0A0C4DGE4
swissprot - E9PQJ8
swissprot - Q13277
swissprot - E9PN33
Ensembl - ENSG00000166900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STX3ENSDARG00000051981Danio rerio
 stx3aENSDARG00000001880Danio rerio
 Stx3ENSMUSG00000041488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STX2 / P32856 / syntaxin 2ENSG0000011145063
STX1A / Q16623 / syntaxin 1AENSG0000010608963
STX1B / P61266 / syntaxin 1BENSG0000009936561
STX4 / Q12846 / syntaxin 4ENSG0000010349639
STX11 / O75558 / syntaxin 11ENSG0000013560429
STX19 / Q8N4C7 / syntaxin 19ENSG0000017875028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE
 IPR031186  Syntaxin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016081 synaptic vesicle docking IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0050921 positive regulation of chemotaxis IMP
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0061025 membrane fusion IEA
 biological_processGO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 biological_processGO:2000010 positive regulation of protein localization to cell surface IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005773 vacuole TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031201 SNARE complex ISS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042581 specific granule IDA
 cellular_componentGO:0042582 azurophil granule IDA
 cellular_componentGO:0042589 zymogen granule membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097470 ribbon synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:1990796 photoreceptor cell terminal bouton IEA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050544 arachidonic acid binding ISS


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000121 Nephrocalcinosis 
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 HP:0000989 Pruritus "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." [HPO:curators]
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 HP:0001263 Developmental retardation "A delay in the achievement of motor or mental milestones manifested prior to age 18 and generally associated with lifelong mental and/or physical impairments." [HPO:curators]
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 HP:0001942 Metabolic acidosis 
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 HP:0001944 Dehydration 
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 HP:0002014 Diarrhea 
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 HP:0003270 Abdominal distention "Enlargement or distention of the abdomen, which can be a secondary feature associated with a number of conditions such as bowel obstruction." [HPO:curators]
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 HP:0011106 Hypovolemia "An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood." [HPO:probinson]
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 HP:0011473 Villous atrophy "The enteric villi are atrophic or absent." [HPO:probinson]
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 HP:0012211 Abnormal renal physiology "Any functional anomaly of the `kidney` (FMA:7203)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000084652 TXLNA / P40222 / taxilin alpha  / complex / reaction






 

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