ENSG00000106089


Homo sapiens

Features
Gene ID: ENSG00000106089
  
Biological name :STX1A
  
Synonyms : Q16623 / STX1A / syntaxin 1A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q11.23
Gene start: 73699206
Gene end: 73719672
  
Corresponding Affymetrix probe sets: 204729_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378583
Ensembl peptide - ENSP00000378585
Ensembl peptide - ENSP00000378584
Ensembl peptide - ENSP00000222812
NCBI entrez gene - 6804     See in Manteia.
OMIM - 186590
RefSeq - NM_004603
RefSeq - XM_017012567
RefSeq - NM_001165903
RefSeq Peptide - NP_001159375
RefSeq Peptide - NP_004594
swissprot - A0A0C4DFZ1
swissprot - Q16623
swissprot - Q75ME0
swissprot - A8MZ54
Ensembl - ENSG00000106089
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx1aENSDARG00000058994Danio rerio
 STX1AENSGALG00000041722Gallus gallus
 Stx1aENSMUSG00000007207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STX1B / P61266 / syntaxin 1BENSG0000009936583
STX2 / P32856 / syntaxin 2ENSG0000011145064
STX3 / Q13277 / syntaxin 3ENSG0000016690063
STX4 / Q12846 / syntaxin 4ENSG0000010349645
STX11 / O75558 / syntaxin 11ENSG0000013560430
STX19 / Q8N4C7 / syntaxin 19ENSG0000017875030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE
 IPR028669  Syntaxin 1A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010701 positive regulation of norepinephrine secretion ISS
 biological_processGO:0010807 regulation of synaptic vesicle priming IEA
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0016081 synaptic vesicle docking IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 biological_processGO:0032940 secretion by cell IDA
 biological_processGO:0033605 positive regulation of catecholamine secretion ISS
 biological_processGO:0035493 SNARE complex assembly IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis ISS
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031201 SNARE complex TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0042641 actomyosin IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IEA
 cellular_componentGO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
 cellular_componentGO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017022 myosin binding IBA
 molecular_functionGO:0019855 calcium channel inhibitor activity IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IDA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0032028 myosin head/neck binding IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Insulin processing
Regulation of insulin secretion
Other interleukin signaling
Toxicity of botulinum toxin type C (BoNT/C)
LGI-ADAM interactions
Neurexins and neuroligins
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001738 Exocrine pancreatic insufficiency 
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 HP:0002024 Malabsorption 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0002206 Pulmonary fibrosis 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002613 Biliary cirrhosis 
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 HP:0002721 Immunodeficiency 
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 HP:0004313 Reduced immunoglobulin levels 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132639 P60880 / SNAP25 / synaptosome associated protein 25  / complex
 ENSG00000168481 LGI3 / Q8N145 / leucine rich repeat LGI family member 3  / reaction / complex
 ENSG00000076944 Q15833 / STXBP2 / syntaxin binding protein 2  / complex
 ENSG00000136854 P61764 / STXBP1 / syntaxin binding protein 1  / complex
 ENSG00000220205 VAMP2 / P63027 / vesicle associated membrane protein 2  / complex
 ENSG00000011132 APBA3 / O96018 / amyloid beta precursor protein binding family A member 3  / complex
 ENSG00000084652 TXLNA / P40222 / taxilin alpha  / reaction / complex






 

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